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Application of Raman Spectroscopy in Rapid Detection of New-Type Drugs |
SUI Cheng-hua1, 2*,TU Qian1,YAN Bo1, 2,CHEN Nai-bo1, 2,LU Zhong1, 2,Lü Bin1, 2 |
1. College of Science, Zhejiang University of Technology, Hangzhou 310023, China
2. Collaborative Innovation Center for Information Technology in Biological and Medical Physics, Hangzhou 310023, China |
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Abstract The increasing spread and rapid updating of new-type drugs have put forward higher and higher requirements for the rapid detection by law enforcement departments. In this paper, Raman spectroscopy in the rapid detection of new-type drugs was studied by theoretical calculation and experimental detection of three typical new-type drugs. The molecules of the three drugs were optimized and calculated by B3LYP hybrid functional and 6-31G basis set. The Raman spectrometer was used for the experimental detection. The results indicated that the theoretical Raman spectra tallies with the experimental Raman spectra, and can be used for providing a reference for the attribution of experimental spectral peaks. The Raman peak positions of the three drugs are significantly different. The characteristic Raman peaks of methamphetamine are located at 837 and 1 003 cm-1. Those of ketamine are located at 463,659 and 1 046 cm-1. And the most obvious characteristic peaks of Ma Gu are located at 556, 1 329 and 1 699 cm-1. Clearly the Raman spectra can be used for the identification of drugs. The Raman spectra of methamphetamine and ketamine residues tally with those obtained from the constant samples, which just shows that drug residues can be accurately identified by Raman spectroscopy. The characteristic Raman peak of pseudomethamphetamine (N-benzylisopropylamine) 853 cm-1 is significantly different from that of methamphetamine 837 cm-1. Therefore the Raman spectra can also be used to identify the authenticity of new-type drugs. Moreover, transparent packaging has a great influence on the Raman spectrum of Ma Gu which has strong fluorescence interference.
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Received: 2017-11-24
Accepted: 2018-04-01
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Corresponding Authors:
SUI Cheng-hua
E-mail: suich@zjut.edu.cn
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[1] QIU Hui, LE Sheng, WU Feng-bo(邱 晖, 乐 胜, 吴逢博). Guangdong Chemical Industry(广东化工), 2016, 43(19): 178.
[2] LU Xiao-han, YANG Tian(陆笑寒, 杨 甜). Studies of Trace Elements and Health(微量元素与健康), 2014, 31(03): 58.
[3] ZHAI Wan-feng, ZHANG Chun-shui, GAO Li-sheng(翟晚枫, 张春水, 高利生). Chinese Journal of Drug Abuse Prevention and Treatment(中国药物滥用防治杂志), 2014, 20(5): 270.
[4] Triplett J S, Hatfield J A, Kaeff T L. Journal of Forensic Sciences, 2013, 58(6): 1607.
[5] WANG Qing-hua, WANG Rao, WANG Yan-jun(王清华, 王 尧, 王燕军). Forensic Science and Technology(刑事技术), 2014, (5): 33.
[6] Yang Y, Li Z Y, Yamaguchi K. Nanoscale, 2012, 4(8): 2663.
[7] MIAO Cui-ying, ZHOU Lu-zhi, QIAN Zun-lei(苗翠英, 周鲁智, 钱尊磊). Journal of People’s Public Security University of China·Science and Technology(中国人民公安大学学报·自然科学版), 2016, 22(3): 34.
[8] DI Yu-min, ZHANG Kai, XIAO Nan(邸玉敏, 张 凯, 肖 楠). Forensic Science and Technology(刑事技术), 2012, (2): 63.
[9] XIAO Ming-yao(肖明耀). Error Theory and its Applications(误差理论与应用). Beijing: Metrology Publishing House(北京: 计量出版社), 1985.
[10] ZHANG Xun, CHEN Sheng, WU Bo-shi, et al(张 逊, 陈 胜, 吴博士, 等). Chinese Journal of Analytical Chemistry(分析化学), 2016, 44(12): 1846.
[11] SU Ya-qiong, WU De-yin, TIAN Zhong-qun(苏亚琼, 吴德印, 田中群). Acta Physico-Chimica Sinica(物理化学学报), 2014, 30(11): 1993.
[12] HUANG Shuang-gen, WU Yan, HU Jian-ping, et al(黄双根, 吴 燕, 胡建平, 等). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2017, 37(1): 135.
[13] WANG Lei, LI Lai-cai(王 磊, 李来才). Journal of Sichuan Normal University·Natural Science(四川师范大学学报·自然科学版), 2013, 36(01): 92.
[14] DONG Kun, RAO Zhi-fan, YANG Xiao-yun, et al(董 鹍, 饶之帆, 杨晓云, 等). China Plastics Industry(中国塑料工业), 2011, 39(6): 67. |
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