| 光谱学与光谱分析 |
|
|
|
|
|
| Study on the Interaction of Anticancer Drugs and DNA Using Fluorescence Spectroscopy |
| SHEN Jing-shan1, SUN Dan-dan2, FU Lian-chun4, Lü Wen-bo1, Lü Guo-wei1, YE Xue-min1, MENG Guang-zheng3, SONG Zeng-fu1* |
1. School of Physics, Peking University, Beijing 100871, China
2. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
3. Central Iron and Steel Research Institute, Beijing 100081, China
4. CTA-Tex Chemicals, Beijing 100025, China |
|
|
|
|
Abstract Fluorescence spectroscopy has achieved great successes in the study on the interaction of drugs and DNA in both quantitative analysis and qualitative analysis. While the fluorescence probe technique can be used to measure the intensity of drugs-DNA interaction, because the injected drugs can change the fluorescence intensity of the probe. In this paper, the authors use berberine as a probe to measure the interaction intensity between some anticancer drugs and DNA, calculate the constant D and determine the effects of those drugs. In addition, the authors point out that this method can not be efficient for certain drug solution.
|
|
Received: 2003-05-20
Accepted: 2003-08-08
|
|
|
|
Corresponding Authors:
SONG Zeng-fu
|
|
| Cite this article: |
|
SHEN Jing-shan,SUN Dan-dan,FU Lian-chun, et al. Study on the Interaction of Anticancer Drugs and DNA Using Fluorescence Spectroscopy [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(02): 232-234.
|
|
|
|
| URL: |
|
https://www.gpxygpfx.com/EN/Y2005/V25/I02/232 |
[1] DING Dao-yuan，HU Jie-han，PＩAO Yong-xu(丁道远, 胡皆汉, 朴勇旭). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，1990, 10(2)：24.
[2] HE Ji-xiang, JIANG Chong-qiu, GAO Ming-xia(贺吉香，江崇球，高明霞). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，2003，23(4)：７５５.
[3] ZHAO Chang-chun, ZHENG Wei-fa, LI Meng-qiu(赵长春，郑维发，李梦秋). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，2004，24(1)：111.
[4] DINＧ Xiao-ping, XIA Mei-ying, ZHOU Ya-qin, MENG Chao, MENG Guang-zheng(丁小平, 肖枚英, 周雅琴，孟 超，孟广政). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，1997，17(2): 8.
|
| [1] |
YI Min-na1, 2, 3, CAO Hui-min1, 2, 3*, LI Shuang-na-si1, 2, 3, ZHANG Zhu-shan-ying1, 2, 3, ZHU Chun-nan1, 2, 3. A Novel Dual Emission Carbon Point Ratio Fluorescent Probe for Rapid Detection of Lead Ions[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(12): 3788-3793. |
| [2] |
HE Yan-ping, WANG Xin, LI Hao-yang, LI Dong, CHEN Jin-quan, XU Jian-hua*. Room Temperature Synthesis of Polychromatic Tunable Luminescent Carbon Dots and Its Application in Sensitive Detection of Hemoglobin[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(11): 3365-3371. |
| [3] |
YE Zi-yi, LIU Shuang, ZHANG Xin-feng*. Screening of DNA Dyes for Colorimetric Sensing Via Rapidly Inducing Gold Nanoparticles Aggregation[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(09): 2805-2810. |
| [4] |
LENG Jun-qiang, LAN Xin-yu, JIANG Wen-shuo, XIAO Jia-yue, LIU Tian-xin, LIU Zhen-bo*. Molecular Fluorescent Probe for Detection of Metal Ions[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(07): 2002-2011. |
| [5] |
QIAN Duo, SU Wen-en, LIU Zhi-yuan, GAO Xiao-yu, YI Yu-xin, HU Cong-cong, LIU Bin, YANG Sheng-yuan*. Soy Protein Gold Nanocluster as an “Off-On” Fluorescent Probe for the Detection of Bacillus Anthracis Biomarkers DPA[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(06): 1815-1820. |
| [6] |
ZHENG Li-zhen1, 2, CHENG Cong2, MA Wen-hua2, WANG Zhuo-rui2, HU Dao-dao2*. Online Detection of Water Forms and Moisture Volatilization Behavior in Earthen Relics Based on FE Fluorescence Probe[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(02): 383-388. |
| [7] |
LÜ Chun-qiu1, SI Lu-lu1, PAN Zhao-jin2, LIANG Yang-lin1, LIAO Xiu-fen2, CHEN Cong-jin2*. Fast and Ratiometric Detection of Dimethoate Via the Dual- Emission Center Nitrogen-Doped Carbon Quantum Dots[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(02): 468-474. |
| [8] |
ZHAI Yan-ke1, PAN Yi-xing1, XIANG Hao1, XU Li1*, ZHU Ze-ce2, LEI Mi1. Coordination Interaction of DSAZn With Quercetin and High Sensitivity Detection of Quercetin[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(01): 122-128. |
| [9] |
SONG Jiang-tao, YUAN Yue-hua, ZHU Yong-jun, WANG Yu-zhen, TIAN Mao-zhong*, FENG Feng*. Research Progress of Near-Infrared Fluorescent Probes for Hydrogen Sulfide[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(11): 3321-3329. |
| [10] |
XU Yi-fei, LIU Lu, SHI Shi-kao*, WANG Yue, PAN Yu-jing, MA Xing-wei. Spectroscopic Properties of Carbon Quantum Dots Prepared From Persimmon Leaves and Fluorescent Probe to Fe3+ Ions[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(08): 2418-2422. |
| [11] |
WAN Xiao-ming1, 2, ZENG Wei-bin1, 2, LEI Mei1, 2, CHEN Tong-bin1, 2. Micro-Distribution of Elements and Speciation of Arsenic in the Sporangium of Pteris Vittata[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(02): 478-482. |
| [12] |
LÜ Jia-nan, LI Jun-sheng*, HUANG Guo-xia, YAN Liu-juan, MA Ji. Spectroscopic Analysis on the Interaction of Chrysene With Herring Sperm DNA and Its Influence Factors[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(01): 210-214. |
| [13] |
SUN Xue-peng1, 2, ZHANG Xiao-yun1, 2, SHAO Shang-kun1, 2, WANG Ya-bing1, 2, LI Hui-quan1, 2, SUN Tian-xi1, 2*. A Method Quickly to Measure the Size of the Confocal Volume of Confocal X-Ray Instrument[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(11): 3493-3497. |
| [14] |
LI Meng-yao1, 2, WANG Shu-ya1, XIE Yun-feng1, LIU Yun-guo3*, ZHAI Chen1*. Detection of Protease Deterioration Factor in Tomato by Fluorescence Sensor Array[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(11): 3477-3482. |
| [15] |
JIA Hui-jie, ZHU Ning, GAO Yuan-yuan, WANG Ya-qi, SUO Quan-ling*. Effect of Substituent Structure of Benzothiazole Probe on Recognition to Metal Ion[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(11): 3594-3598. |
|
|
|
|
