|
|
|
|
|
|
| The Proceedings of Raman Spectroscopy in Cervical Cancer in Recent Five Years |
| SHEN Zhuo-wei, LI Rui, WANG Yang, XU Xiao-guang, XIAO Zhen* |
The First Affiliated Hopsital of Dalian Medical Unversity, Dalian 116000, China
|
|
|
|
|
Abstract Cervical cancer is the fourth incidence rate of cancer in women. If we can diagnose cervical cancer and cervical intraepithelial neoplasia early, we can greatly improve survival. The existing diagnostic techniques have the problems of high false-positive rate, low specificity, low sensitivity, time-consuming and high price. Raman spectroscopy is a new and reliable technology which can analyze the molecular structure of substances and the chemical composition of human tissues. In medical research, Raman imaging has been successfully applied to nasopharyngeal carcinoma, gastric cancer, lung cancer, esophageal cancer, renal tumor, cerebral cancer, etc. This review summarizes the key research of Raman spectroscopy in cervical cancer in the recent five years. Raman technology has been used in the study of cervical cancer for decades. In the past five years, we have studied the influence of inflammatory factors on the diagnosis, the differentiation of cervical squamous cell carcinoma and adenocarcinoma. This review summarizes the literature in recent five years from histology in vivo, histology in vitro, cytology and blood. It also summarizes the data processing methods, excitation wavelength, Raman wave number, and representative substances. The existing literature has proved that the specificity and accuracy of Raman spectroscopy in the diagnosis of cervical cancer can reach more than 90%, which is no less than the traditional hematoxylin-eosin (HE) staining. Compared with HE staining, Raman technology has the advantages of no staining, no fixation, less demand for professionals, faster and so on, which provides another feasibility for the diagnosis of cervical cancer. However, more research and evidence are needed to fully demonstrate the role of Raman spectroscopy in the diagnosis of cervical cancer before it is used in the clinic. We are also looking forward to more samples and more research.
|
|
Received: 2021-05-31
Accepted: 2021-09-13
|
|
|
|
Corresponding Authors:
XIAO Zhen
E-mail: seriousdoc@163.com
|
|
[1] Arbyn M, Weiderpass E, Bruni L, et al. The Lancet Global Health, 2020, 8(2): e191.
[2] Ramos I R, Malkin A, Lyng F M. Biomed. Res. Int., 2015, 2015: 561242.
[3] WANG Qian-qian, XIANGLI Wen-ting, TENG Ge-er, et al（王茜蒨, 相里文婷, 腾格尔, 等）. Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2021, 41(4): 1016.
[4] Shaikh R, Prabitha V G, Dora T K, et al. J. Biophotonics, 2017, 10(2): 242.
[5] Daniel A, Prakasarao A, Dornadula K, et al. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2016, 152: 58.
[6] Daniel A, Prakasarao A, Ganesan S. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 190: 409.
[7] Wang J, Zheng C X, Ma C L, et al. Lasers Med. Sci., 2021, 36: 1855.
[8] Zheng C, Qing S, Wang J, et al. Photodiagnosis Photodyn. Ther., 2019, 27: 156.
[9] Zhang H, Chen C, Gao R, et al. Photodiagnosis Photodyn. Ther., 2021, 33: 102104.
[10] Duraipandian S, Traynor D, Kearney P, et al. Sci. Rep., 2018, 8(1): 15048.
[11] Aljakouch K, Hilal Z, Daho I, et al. Anal. Chem., 2019, 91(21): 13900.
[12] Sitarz K, Czamara K, Bialecka J, et al. Int. J. Mol. Sci., 2020, 21(8): 2667.
[13] Karunakaran V, Saritha V N, Joseph M M, et al. Nanomedicine, 2020, 29：102276.
[14] Lu D, Ran M, Liu Y, et al. Anal. Bioanal. Chem., 2020, 412(26): 7099.
|
| [1] |
WANG Qian-qian, XIANGLI Wen-ting, TENG Geer, CUI Xu-tai, WEI Kai. Advance in Raman Spectroscopy for Pathological Diagnosis[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(04): 1016-1022. |
| [2] |
LUO Lin-lin1, 2, 3, NIU Jing-jing3, MO Bei-xin1, 2, LIN Dan-ying3, LIU Lin1, 2*. Advances in the Application of Förster Resonance Energy Transfer and Fluorescence Lifetime Imaging Microscopy （FRET-FLIM） Technique in Life Science Research[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(04): 1023-1031. |
| [3] |
YI Ding-rong1, ZHAO Yan-li1, KONG Ling-hua2*, WANG Wen-qi1, HUANG Cai-hong1. Miniature Snapshot Narrow Band Multi-Spectral Imaging Technology for Cervical Cancer Screening[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(01): 157-161. |
| [4] |
LIN Xiao-gang, PAN Ying-jun, GUO Yong-cai, ZHANG Wei, ZHAO Yi-shi . The Study of Cervical Cancer Cells Model Based on UV Absorption Spectrum[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2009, 29(09): 2547-2550. |
| [5] |
YANG Zhan-guo, QI Jian, ZHANG Guang-shui, SU Ming-jie, ZHANG Feng-qiu* . FTIR Spectroscopic Analysis of HeLa Cell Irradiated by Low-Energy Ions [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2009, 29(09): 2409-2412. |
| [6] |
ZHANG Feng-qiu,HAO Yuan-li,E Xiang-hong,IU Wei,HANG Guang-shui,IN Guang-yong. Absorption Spectrum Study of HeLa Cells Treated with Vacuum and Low-Energy Ions Implantation[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2009, 29(08): 2034-2037. |
| [7] |
ZHAO Zhi-min,XIN Yu-jun, WANG Le-xin, ZHU Wei-hua,ZHENG Min,GUO Xin. Measurement and Analysis of Absorption Spectrum of Human Blood[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2008, 28(01): 138-140. |
|
|
|
|
