The Solution of Nonlinear Function of Ion Mobility Based on FAIMS Spectrum Peak Position
WANG Dian-ling1, 2, CHEN Chi-lai1*, ZHAO Cong1, 2, GAO Jun1, KONG De-yi1, YOU Hui1, Juergen Brugger3
1. State Key Laboratory of Transducer Technology, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, China 2. Department of Automation，University of Science and Technology of China, Hefei 230027, China 3. Microsystems Laboratory, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Abstract：FAIMS’s ion separation mechanism is based on analyte’s characteristic nonlinear relationship between its ion mobility and applied electric field strength. Present characterization methods for this nonlinear relationship are based on precarious assumptions which incur substantial errors under many circumstances. A rigorous method for solving the second and fourth taylor series coefficient of this relationship based on dispersion voltage value (assuming half-sinusoidal waveform) and associated compensation voltage value of spectrum peak is presented, alongside with rigorous analytical functions. FAIMS spectrums were obtained for ethanol, metaxylene and n-butanol using custom-built FAIMS spectrometer, and corresponding second and fourth taylor series coefficients were obtained with the proposed method. Evaluation shows that this method substantially reduces the RMS error between interpolated and measured peak compensation voltage values under different dispersion voltages, confirming its superiority over present methods. This rigorous method would help improve spectral resolutions of FAIMS spectrometer, facilitating high precision FAIMS spectrum database construction and accurate analyte discrimination.
Key words：Nonlinear function of ion mobility;FAIMS spectrum;Second and fourth coefficients
王电令1,2，陈池来1*，赵 聪1,2，高 钧1，孔德义1，尤 晖1，Juergen Brugger3 . 基于FAIMS谱图峰位置的离子迁移率非线性函数解析[J]. 光谱学与光谱分析, 2012, 32(08): 2050-2055.
WANG Dian-ling1, 2, CHEN Chi-lai1*, ZHAO Cong1, 2, GAO Jun1, KONG De-yi1, YOU Hui1, Juergen Brugger3 . The Solution of Nonlinear Function of Ion Mobility Based on FAIMS Spectrum Peak Position. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2012, 32(08): 2050-2055.
[1] Cohen M J，Karasek F W. J. Chromatogr. Sci.，1970，8(6)：330. [2] Sielemann S，Horvath T，Teepe M，et al. Int. J. Mass Spectrom. Ion Processes，2002，5：19. [3] Eiceman G A，Schmidt H，Rodriguez J E，et al. Instrum Sci. Technol. ，2007，35(4)：365. [4] Borsdorf H，Nazarov E G，Miller R A. Talanta，2007，71(4)：1804. [5] Canterbury J D，Yi X H，Hoopmann M R，et al. Anal. Chem. ，2008，80(18)：6888. [6] Drexler D M，Garrett T J，Cantone J L，et al. J. Pharmacol. Toxicol. Methods，2007，55(3)：279. [7] Hogan C J，de la Mora J F. PCCP，2009，11(36)：8079. [8] Ells B，Barnett D A，Purves R W，et al. J. Environ. Monitng，2000，2(5)：393. [9] Kolakowski B M，Mester Z. Analyst，2007，132(9)：842. [10] Hatsis P，Kapron J T. Rapid Commu. In Mass Spectrom. 2008，22(5)：735. [11] CHEN Chi-lai，KONG De-yi，WANG Xiao-hua，et al(陈池来，孔德义，汪小华，等). Chin. J. Anal. Chem.(分析化学)，2011，24(3)：325. [12] LI Zhuang，LIN Bing-tao，KONG De-yi，et al(李 庄, 林丙涛, 孔德义，等). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，2010，31(1)：12. [13] Buryakov I A，Krylov E V，Nazarov E G，et al. Int. J. Mass Spectrom. Ion Processes，1993，128(3)：143. [14] Shvartsburg A A，Smith R D. J. Am. Soc. Mass Spectrom.，2008，19(9)：1286. [15] Viehland L A，Guevremont R，Purves RW，et al. Int. J. Mass Spectrom. 2000，197：123. [16] Handy R，Barnett D A，Purves R W，et al. J. Anal. At. Spectrom.，2000，15(8)：907. [17] Guevremont R，Barnett D A，Purves R W，et al. J. Chem. Phys.，2001, 114(23)：10270. [18] Buryakov I A. Tech. Phys.，2004，49(8)：967. [19] Shvartsburg A A，Tang K，Smith R D. J. Am. Soc. Mass Spectrom.，2005，16(1)：2. [20] SHI Ying-guo，SHAO Shi-yong，LI An-lin，et al(时迎国，劭士勇，李安林，等). Chin. J. Anal. Chem.(分析化学)，2006，34(9)：1353. [21] LIN Bing-tao，CHEN Chi-lai，KONG De-yi，et al(林丙涛，陈池来，孔德义，等). Chin. J. Anal. Chem.(分析化学)，2010，38(7)：1027. [22] Bell S，Nararov E，Wang Y F，et al. Anal. Chem. Acta，1999，394(2-3)：121.
