The Action Mechanism of 8-Azaadenine and Its Metal Complexes with DNA
XI Xiao-li, YANG Man-man,YANG Pin*
Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China
Abstract：The mechanism of the interactions of 8-azaadenine and its Co2+ and Cu2+ complexes with DNA was studied by UV and fluorescence spectra using ethidium bromide(EB) as the probe molecule. When pH 9.86, the action of 8-azaadenine-Co2+ with DNA was electrostatic effect and certain kind of intercalation action, when pH 7.4, the action of 8-azaadenine-Cu2+ with DNA was intercalation action and certain kind of electrostatic effect, when pH 2.85, the action was intercalation action and certain kind of electrostatic effect. But when pH 7.4, 8-azaadenine hardly influenced the intercalation action of EB and DNA, and the action of 8-azaadenine and DNA was electrostatic action.
Key words：8-azaadenine metal complex;DNA;Scatchard plots
席小莉，杨曼曼，杨频*. 8-氮杂腺嘌呤及其金属配合物与DNA的作用机理[J]. 光谱学与光谱分析, 2006, 26(12): 2272-2275.
XI Xiao-li, YANG Man-man,YANG Pin*. The Action Mechanism of 8-Azaadenine and Its Metal Complexes with DNA. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(12): 2272-2275.
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