Synthesis, Crystal Structure and DNA/BSA Interaction of a Ni(Ⅱ) Coordination Compound
PENG Chen-jia1, WANG Ke-hua1*, LU Wei-xue1, GUAN Chun-qian1, HU Ya-jing1, MA Shuang1, ZHU Ming-chang2, GAO En-jun2
1. School of Chemistry and Life Science, Anshan Normal University, Anshan 114007, China
2. Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China
Abstract：A Ni(Ⅱ) coordination complex [Ni(2,2′-biby) (H2O)4]·(tba)2·5H2O(2,2′-biby=2,2′-dipyridine, H2tba=2-thiobarbituric acid ) has been synthesized and structurally characterized by IR, element analysis and single crystal X-ray diffractometry. The results of single crystal X-ray diffractometry displayed that the title compound belongs to orthorhombic with space group of Pbca, and its cell parameters are a=13.662(2)Å，b=19.470(4)Å，c=21.590(4)Å. The binding of title compound with Herring sperm DNA/BSA has been investigated by absorption and fluorescence spectra, and the results displayed that the title compound binds with DNA in electrostatic interaction mode, and quenches the intrinsic fluorescence of BSA by a static quenching mechanism.
Key words：Coordination complexes; DNA binding; BSA binding; Crystal structure
[1] Pages B J, Ang D L, Wright E P, et al. Dalton Transactions, 2015, 44：3505.
[2] Wang K H, Gao E J. Anti-Cancer Agents in Medicinal Chemistry, 2014, 14: 147.
[3] WANG Jia-min, SHI Lei, LIU Hai-yang(王家敏, 史 蕾，刘海洋). Progress in Chemistry(化学进展)，2015, 27(6)：755.
[4] Brabec V, Hrabina O, Kasparkova J. Coordination Chemistry Reviews, 2017, 351(15): 2.
[5] Amable L. Pharmacological Research, 2016, 106, 27.
[6] FENG Yang, LI Chuan-bi, ZHAO Li-ting, et al（冯 洋, 李传碧, 赵丽婷, 等). Chinese Journal of Applied Chemistry(应用化学)，2016, 8: 913.
[7] Golovnev N N, Molokeev M S, Sterkhova I V, et al. Journal of Coordination Chemistry, 2016, 21: 3219.
[8] Golovnev N N, Molokeev M S, Vereshchagin S N, et al. Journal of Coordination Chemistry, 2015, 11: 1865.
[9] Wang C, Zhou M S, Yang L J, et al. Chinese Journal of Structural Chemistry, 2017, 36(7): 1210.
[10] Sheldrick G M. Acta Crystallographica Section C, 2015, C71: 3.
[11] Dolomanov O V, Bourhis L J, Gildea R J, et al. Journal of Applied Crystallography, 2009, 42(3): 339.
[12] WEI Qiang, DONG Jian-fang, LI Wen-bin, et al(魏 强, 董建方, 李文彬, 等). Chinese Journal of Inorganic Chemistry(无机化学学报), 2016, 32(5): 789.
[13] Wang K H, Zhu M C, Wang D L, et al. Journal of Structural Chemistry，2015, 56(1): 191.
[14] Zhu M C, Cui X T, Zhao F C, et al. RSC Advances, 2015, 5：47798.
[15] FENG Yong-lan, ZHENG Jian-hua, JIANG Wu-jiu, et al(冯泳兰, 郑建华, 蒋伍玖, 等). Chinese Journal of Inorganic Chemistry(无机化学学报), 2014, 12：2767.
[16] Hu J Y, Liao C L, Guo Y, et al. Polyhedron, 2017, 132: 28.
[17] Sathiyaraj S, Buthcer R J, Jayabalakrishnan C. Journal of Molecular Structure, 2012, 1030: 95.
[18] LIU Yan-cheng, WANG Hai-lu, LIANG Wei-qian, et al(刘延成, 王海璐, 梁炜乾, 等). Journal of Instrumental Analysis(分析测试学报), 2011, 12：1400.
[19] Lakowicz J F. Principles of Fluorescence Spectroscopy, 2nd ed. Plenum Press, New York, 1999. 237.
[20] Zhou X Q, Sun Q, Jiang L, et al. Dalton Transactions, 2015, 44：9516.
[21] Anbazhagan V, Renganathan R. Journal of Luminescence, 2008, 128：1454.
