Study on Molecular Recognition of Cucurbit[6]uril with Oxytetracycline Molecules by Spectroscopic Methods
YAN Kun1, 2, WANG Ping1, LIU Yun2*, DONG Yuan-hua2
1. School of Chemistry & Biological, Lanzhou Jiaotong University, Lanzhou 730070, China 2. Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China
Abstract：The molecular recognition of Cucurbit[6]uril (CB[6]) with Oxytetracycline (OTC) was studied by fluorescence spectra and UV spectra. The results showed that the fluorescence intensity and the UV absorbance of OTC were enhanced as host molecules were added, which showed that CB[6] and OTC were interacted. The inclusion of OTC was detected by fluorescence spectra and UV spectra with an apparent 1∶1 interaction, which was also observed through the Benesi-Hildebrand method, OTC can form 1∶1 complex with CB[6] under acid condition and it can not form complex with CB[6] under basic condition. The thermodynamic parameters (stability constants Ks, Gibbs free energy change ΔG, enthalpy change, and entropy change) for the complexation process were determined. The thermodynamic studies indicated that the inclusion reactions between CB[6] and OTC were the hydrophobic interaction and endothermic process.
严 昆1,2，王 萍1，刘 云2*，董元华2 . 光谱法研究葫芦[6]脲与土霉素的分子识别作用 [J]. 光谱学与光谱分析, 2017, 37(02): 641-645.
YAN Kun1, 2, WANG Ping1, LIU Yun2*, DONG Yuan-hua2 . Study on Molecular Recognition of Cucurbit[6]uril with Oxytetracycline Molecules by Spectroscopic Methods. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2017, 37(02): 641-645.
[1] Buschmann H J, Jansen K, Schollmeyer E. Inorganic Chemistry Communications, 2003, 6(5): 531. [2] Klock C, Dsouza R N, Nau W M. Organic Letters, 2009, 11(12): 2595. [3] Liu Yu, Ke Chenfang, Zhang Hengyi, et al. Journal of Organic Chemistry, 2007, 72(1): 280. [4] Jin Tao, Chen Deqiang, Liu Yun. Journal of Environmental Sciences, 2013, 33(4): 991. [5] Qiao Hongtao, Wang Ping, Liu Yun. New Chemical Materials, 2013, 41(7): 82. [6] Qiao Hongtao, Liu Yun, Dong Yuanhua, et al. Salination and Water Treatment, 2013, 54(2015): 113. [7] Chen Ruihuan, Qiao Hongtao, Liu Yun, et al. Environmental Progress & Sustainable Energy, 2015, 34(2): 512. [8] Li Xialin. China Modern Medicine, 2010, 17(27): 17. [9] Yang Kaijin. Chinese Journal of Primary Medicine and Pharmacy, 2006, 13(7): 1204. [10] Benesi H A, Hildebrand J H. Journal of the American Chemical Society, 1949, 71(8): 2703. [11] Xu Hao, Chen Liang, Ma Lihua. Analysis and Testing Technology and Instruments, 2002, 8(2): 72. [12] Ross P D, Subramanian S. Biochemisty, 1981, 20(11): 3096.
