| 光谱学与光谱分析 |
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| Synthesis and Spectral Analysis of Three Kinds of Epoxy Pregnene Derivatives |
| YIN Hai-bin,ZHENG Hu |
| West China School of Pharmacy, Sichuan University, Chengdu 610041, China |
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Abstract Three kinds of derivatives, 16α,17α-epoxy-6-methylene-pregn-4-ene-3,20-dione(EMPD Ⅰ), 16α,17α-epoxy-6-methyl-pregn-4,6-diene-3,20-dione (EMPD Ⅱ) and 16α,17α-epoxy-6-methyl-pregn-4-ene-3,20-dione(EMPD Ⅲ) were synthesized and their FTIR，UV and 1H NMR spectra were described. EMPD Ⅱ is a novel compound. In the UV spectra, the maximum absorptions peaks of EMPD Ⅰ, EMPD Ⅱ and EMPD Ⅲ are at 259, 287 and 239 nm respectively. Their IR spectra are also obviously different. For EMPD Ⅰ, there are two absorption peaks, which are respectively at 3 084 cm-1 originated from CH2 and 3 030 cm-1 from CCH. For EMPD Ⅱ and Ⅲ, there is only one absorption peak at 3 054 cm-1. From 1 710-1 660 cm-1,only one absorption peak appears for EMPD Ⅲ, but two appear for EMPD Ⅰ and EMPD Ⅱ. In 1H NMR spectrum, the peaks at 4.92(s, 1H), 5.06(s, 1H) and 5.88(s, 1H) were observed for EMPD Ⅰ; the peaks at 1.83(s, 3H), 5.87(s, 1H) and 5.85(s, 1H) for EMPD Ⅱ; while the peaks at 1.06-1.07(d, 3H), 5.78 ppm(s, 1H, 1 ppm=1 μg·mL-1), for EMPD Ⅲ.
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Received: 2006-05-08
Accepted: 2006-08-16
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Corresponding Authors:
YIN Hai-bin
E-mail: hmikeyin@hotmail.com
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| Cite this article: |
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YIN Hai-bin,ZHENG Hu. Synthesis and Spectral Analysis of Three Kinds of Epoxy Pregnene Derivatives[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(05): 966-968.
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| URL: |
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https://www.gpxygpfx.com/EN/Y2007/V27/I05/966 |
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