|
|
|
|
|
|
Oxygen Concentration Detection and Calibration Method Improvement in Pharmaceutical Vial Based on Wavelength Modulation Spectroscopy |
ZHU Gao-feng1,2, YANG Chun-hua1, ZHU Hong-qiu1*, GUI Wei-hua1 |
1. School of Information Science and Engineering, Central South University, Changsha 410083, China
2. School of Information, Hunan University of Humanities, Science and Technology, Loudi 417000, China |
|
|
Abstract Pharmaceutical vial’s oxygen concentration detection based on wavelength modulation spectroscopy (WMS) was conducted on a single, short optical path in the open. The oxygen absorption lines at 760.885 nm (13 142.58 cm-1 ) were chosen- and the system parameters were optimized. Then, data processing method and steps were explained, such as real-time background deduction and real-time spectrum correction. Seven samples of the different oxygen concentrations were tested, and the corresponding second harmonic signals were obtained. Finally, the linear regression equations were established between the concentration and the peak height(C—H), the peak area at half maximum(C—A). The experimental results indicated that the fitting coefficients of two methods were 0.996 6 and 0.997 8, respectively, and the latter was increased by 0.12 % than the former. Prediction accuracy of the model was evaluated by fully interactive authentication method and the results indicated that the root mean square errors of prediction (RMSEP) were 0.003 1 and 0.002 0, respectively, and the latter was reduced by 37.69% than the former. The 2f signal of sample ( 4%) were severally measured for 20 times by the two methods in different time and the results indicated that standard deviations were 0.002 2 and 0.001 6, respectively, and the latter was reduced by 27.3% than the former. Meanwhile, the resolutions were 0.198% and 0.097%, respectively, and the latter was increased by 51% than the former. The system is feasible to measure the pharmaceutical vial’s oxygen concentration, and the accuracy and stability of the system can be improved by the C—A method.
|
Received: 2016-04-25
Accepted: 2016-08-19
|
|
Corresponding Authors:
ZHU Hong-qiu
E-mail: hqcsu@csu.edu.cn
|
|
[1] Sun K, Sur R, Jeffries J B, et al. Appl. Phys. B, 2014, 117(1): 411.
[2] Li J, Parchatka U, Fischer H. Appl. Phys. B, 2012, 108(4): 951.
[3] Michael B Frish, Richard T Wainner, et al. IEEE Sensors Journal, 2010, 10(3): 639.
[4] Neethu S, Verma R, Kamble S S, et al. Sensors and Actuators B, 2014, 192: 70.
[5] Qi Rubin, Du Zhenhui, Gao Dongyu, et al. Chinese Optics Letters, 2012, 3: 033001(1-4).
[6] Goldenstein C S, Almodóvar C A, Jeffries J B, et al. Measurement Science and Technology, 2014, 25: 105104.
[7] Gao Guangzhen, Chen Baoxue, Hu Bo. Measurement, 2013, 46: 1657.
[8] Meng Yunxia, Liu Tiegen, Liu Kun, et al. IEEE Photonics Journal, 2014, 6(6): 6803209.
[9] Hartmann A, Strzoda R, Schrobenhauser R, et al. Journal of Quantitative Spectroscopy & Radiative Transfer, 2014, 133: 619.
[10] Abhishek Upadhyay, Arup Lal Chakraborty. IEEE Sensors Journal, 2015, 15(2): 1153.
[11] Bolshov M A, Kuritsyn Yu A, Yu V. Spectrochimica Acta Part B, 2015, 106: 45. |
[1] |
LIANG Wen-ke, WEI Guang-fen, WANG Ming-hao. Research on Methane Detection Error Caused by Lorentzian Profile Approximation[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(06): 1683-1689. |
[2] |
ZHANG Le-wen1, 2, WANG Qian-jin1, 3, SUN Peng-shuai1, PANG Tao1, WU Bian1, XIA Hua1, ZHANG Zhi-rong1, 3, 4, 5*. Analysis of Interference Factors and Study of Temperature Correction Method in Gas Detection by Laser Absorption Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(03): 767-773. |
[3] |
ZHANG Xiao-teng, LIU Wei, LIU Hai-feng*, ZHENG Zun-qing, MING Zhen-yang, CUI Yan-qing, WEN Ming-sheng, YAO Ming-fa. Intensity Distribution and Inversion Reconstruction of Spectrum of
Hydroxyl Radicals in Spray Combustion of PODE Under Different
Environmental Oxygen Concentrations[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(08): 2587-2594. |
[4] |
LIU Jiang-qing1, YU Chang-hui2, 3, GUO Yuan2, 3, LEI Sheng-bin1*, ZHANG Zhen2, 3*. Interaction Between Dipalmityl Phosphatidylcholine and Vitamin B2
Studied by Second Harmonic Spectroscopy and Brewster Angle
Microscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(05): 1484-1489. |
[5] |
WAN Liu-jie1, 2, ZHEN Chao3, QIU Zong-jia1, LI Kang1, MA Feng-xiang3, HAN Dong1, 2, ZHANG Guo-qiang1, 2*. Research of High Precision Photoacoustic Second Harmonic Detection Technology Based on FFT Filter[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(10): 2996-3001. |
[6] |
XIE Ying-chao1,2, WANG Rui-feng1,2, CAO Yuan1,2, LIU Kun1*, GAO Xiao-ming1,2. Research on Detecting CO2 With Off-Beam Quartz-Enhanced Photoacoustic Spectroscopy at 2.004 μm[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(09): 2664-2669. |
[7] |
LI Jin-yi1, FAN Hong-qing1, TIAN Xin-li1, LI Hong-lian2, WU Zhi-chao1, SONG Li-mei1. Pressure Correction for Calibration-Free Measurement of Wavelength Modulation Spectroscopy in Atmospheric Environment[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(05): 1407-1412. |
[8] |
MEI Jiao-xu, WANG Lei*, TAN Tu, LIU Kun, WANG Gui-shi, GAO Xiao-ming. A New Method of DFB Laser Frequency Stabilization Based on the Characteristics of the Second Harmonic[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2019, 39(10): 2989-2992. |
[9] |
LI Chun-guang1, 2, 3, 4, DONG Lei2*, ZHENG Chuan-tao3, WANG Yi-ding3, LIN Jun1*. Mid-Infrared Trace Ethane Sensor Design and Stability Analysis[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2019, 39(03): 959-963. |
[10] |
SHAO Xin, TANG Hai-mei, WANG Feng, LI Yun-long, TAN Pan-long. Research on Closed Indoor Oxygen Concentration of Quasi-Continuous Laser Modulation Absorption Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2018, 38(12): 3713-3717. |
[11] |
ZHU Gao-feng1, 2, HU Xin1, ZHU Hong-qiu1*, HU En-ze1, ZHU Jian-ping3. The Multi-Beam Interference Suppression for Measuring Penicillin Vial’s Oxygen Concentration Based on Tunable Diode Laser Absorption Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2018, 38(02): 372-376. |
[12] |
QU Dong-sheng, HONG Yan-ji*, WANG Guang-yu, PAN Hu, WANG Ming-dong. Wavelength-Modulation Spectroscopy for Measurements of Gas Pressure, Temperature and H2O Concentration in High-Temperature Environment[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2017, 37(05): 1339-1344. |
[13] |
QU Shi-min, WANG Ming, LI Nan . Mid-Infrared Trace CH4 Detector Based on TDLAS-WMS [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2016, 36(10): 3174-3178. |
[14] |
CUI Hai-bin1, YANG Ke1, 2, ZHANG Long1, WU Xiao-song1, LIU Yong1, WANG An1, LI Hui3, JI Min1* . Tunable Diode Laser Absorption Spectroscopy (TDLAS) Detection Signal Denoising Based on Gabor Transform [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2016, 36(09): 2997-3002. |
[15] |
DU Zhen-hui, ZHANG Zhe-yuan, LI Jin-yi, XIONG Bo, ZHEN Wei-meng . The Development of Ammonia Sensor Based on Tunable Diode Laser Absorption Spectroscopy with Hollow Waveguide [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2016, 36(08): 2669-2673. |
|
|
|
|