光谱学与光谱分析 |
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The Study on the Preparation and Spectroscopic Properties of Hydroxypropyl-β-Cyclodextrin/Glipizide Inclusion Complex |
ZHANG Yi-min,LI Xiao,SUN Cong-shan,CHEN Chun-feng |
Key Laboratory for Green Chemical Technology,Ministry of Education,School of Chemical Engineering and Technology, Tianjin University,Tianjin 300072,China |
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Abstract The interaction of glipizide and hydroxypropyl-β-cyclodextrin was investigated in the present paper. The stability constant and molar ratio of glipizide and hydroxypropyl-β-cyclodextrin was calculated from the phase soluility diagram. The solid state inclusion complex of hydroxypropyl-β-cyclodextrin/glipizide prepared by neutralization method was characterized by Fourier transform infrared spectroscopy (FTIR),differential scanning calorimetry (DSC) and powder X-ray diffraction(XRD). It was found that the phase solubility diagram of the HP-β-CD solution showed a typical AL-type,suggesting the formation of a soluble complex of 1∶1 molar ratio,and the stability constant was 359 L·mol-1 at 25 ℃. The spectra of IR, thermograph of DSC and XRD pattern of the inclusion complex were remarkably different from the glipizide and hydroxypropyl-β-cyclodextrin/glipizide physical mixture,and indicated that hydroxypropyl-β-cyclodextrin/glipizide inclusion complex displayed amorphous characteristic. The experiment of solubility of inclusion complex indicated that the solubility of inclusion complex increased 25-fold.
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Received: 2006-11-02
Accepted: 2007-03-06
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Corresponding Authors:
ZHANG Yi-min
E-mail: zhangym001@263.net
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