| 光谱学与光谱分析 |
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| Determination and Pharmacokinetics of Photosensitizer ZnPcS2P2 Uptaken by K562 Cells |
| XIE Bao-gang1，HUANG Hui-fang2，HUANG Jian-dong1*，CHEN Nai-sheng1，HUANG Jin-ling1 |
1. Department of Chemistry, Institute of Research on Functional Materials, Fuzhou University, Fuzhou 350002, China
2. Institute of Haematology, Union Hospital Affiliated to Fujian Medical University，Fuzhou 350001, China |
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Abstract The di-sulfonated di-phthalimidomethyl phthalocyanine zinc(ZnPcS2P2) was an amphiphilic photosensitizer for photodynamic therapy of cancer. According to fluorescence analytical method, extracting efficiencies of 2.0% SDS(Wt%), 1.5% Triton X-100(φ) and DMF for ZnPcS2P2 in K562 cells were compared. The results showed that 1.5% Triton X-100 was the most efficient reagent for the first time extracting. Using 1.5% Triton X-100 as extracting reagent, the kinetic curves of cellular uptake of ZnPcS2P2 as well as LDL-ZnPcS2P2 complex by K562 cells were determined.Compared with ZnPcS2P2，the maximum cellular uptake of LDL-ZnPcS2P2 by K562 was doubled, which indicated that LDL was an effective targeting delivery vehicle for ZnPcS2P2.
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Received: 2003-07-06
Accepted: 2004-01-19
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Corresponding Authors:
HUANG Jian-dong
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| Cite this article: |
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XIE Bao-gang,HUANG Hui-fang,HUANG Jian-dong, et al. Determination and Pharmacokinetics of Photosensitizer ZnPcS2P2 Uptaken by K562 Cells[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2004, 24(11): 1415-1418.
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http://www.gpxygpfx.com/EN/Y2004/V24/I11/1415 |
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