| 光谱学与光谱分析 |
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| Fluorescence Spectrometric Determination of Gatifloxacin by Charge Transfer Reaction |
| AODENG Gao-wa,TAO Yu-long,FAN Hai-yan |
| College of Chemistry and Chemical Engineering,Inner Mongolia University,Hohhot 010021,China |
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Abstract A new method for the determination of gatifloxacin (GFLX) has been developed based on the charge transfer reaction between gatifloxacin as the donor and chloranil(TCBQ) as the acceptor by fluorimetry. Experiments show that GFLX has reacted with TCBQ in a mixture of methanol and water at 45 ℃ for 20 min and the complex was formed. The composition ratio was 1∶1. A linear calibration graph was obtained over the GFLX concentration range from 0.19 to 5.6 mg·L-1 with a detection limit of 0.005 6 mg·L-1. The method has been applied to the determination of GFLX in the preparation,the recoveries are 101.1%-103.9%,and the relative standard deviation is 1.0%-1.9%. At the same time we proposed a method for the determination of GFLX in urine by charge transfer-synchronous fluorescence spectroscopy. Beer’s law is obeyed in the range of 0.023-3.4 mg·L-1 of GFLX with a detection limit of 0.003 4 mg·L-1,the recoveries are 93.9%-101.1%,and the relative standard deviation is 1.0%-1.7%.
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Received: 2006-05-10
Accepted: 2006-08-20
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Corresponding Authors:
AODENG Gao-wa
E-mail: hxgaowa@126.com
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| Cite this article: |
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AODENG Gao-wa,TAO Yu-long,FAN Hai-yan. Fluorescence Spectrometric Determination of Gatifloxacin by Charge Transfer Reaction[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(08): 1615-1618.
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| URL: |
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https://www.gpxygpfx.com/EN/Y2007/V27/I08/1615 |
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