Synthesis, Spectroscopic Characterization and Thermogravimetric Analysis of Cr(Ⅱ), Cu(Ⅱ), Zn(Ⅱ) and Mg(Ⅱ), Captopril Coordination Compounds
Asma S. Al-Wasidi1, Nawal M. Al-Jafshar1, Amal M. Al-Anazi1, Ahmed M. Naglah2, 3*, Robson F. de Farias4, Claudio Airoldi5, Moamen S. Refat6,7
1. Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia
2. Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
3. Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Cairo 12622-Dokki, Egypt
4. Departamento de Química, Universidade Federal do Rio Grande do Norte, Cx. Postal 1664, 59078-970 Natal, Rio Grande do Norte, Brasil
5. Instituto de Química, Universidade Estadual de Campinas, Brasil
6. Chemistry Department, Faculty of Science, Taif University, P.O. Box 888, Al-Hawiah, Taif 21974, Saudi Arabia
7. Department of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt
Synthesis, Spectroscopic Characterization and Thermogravimetric Analysis of Cr(Ⅱ), Cu(Ⅱ), Zn(Ⅱ) and Mg(Ⅱ), Captopril Coordination Compounds
Asma S. Al-Wasidi1, Nawal M. Al-Jafshar1, Amal M. Al-Anazi1, Ahmed M. Naglah2, 3*, Robson F. de Farias4, Claudio Airoldi5, Moamen S. Refat6,7
1. Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia
2. Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
3. Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Cairo 12622-Dokki, Egypt
4. Departamento de Química, Universidade Federal do Rio Grande do Norte, Cx. Postal 1664, 59078-970 Natal, Rio Grande do Norte, Brasil
5. Instituto de Química, Universidade Estadual de Campinas, Brasil
6. Chemistry Department, Faculty of Science, Taif University, P.O. Box 888, Al-Hawiah, Taif 21974, Saudi Arabia
7. Department of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt
摘要： In this work, we have reported the synthesis and spectroscopic characterization of captopril (Cap) coordination compounds: Cu(Cap)·2H2O, Cr(Cap)·H2O, Zn(Cap)·3H2O and Mg(Cap)4. Herein, it is worthily mentioned that the FTIR spectroscopic technique was employed to recognized the nature of coordination between captopril ligand and copper, chromium, zinc and magnesium(Ⅱ) metal ions. In view of the infrared spectroscopic tool, the copper(Ⅱ) metal ion coordinated toward captopril drug ligand through sulfur atom of SH group dependent on the absent of stretching vibration band of —SH. Based on this result, the stretching motion of νa(COO) shifts clearly indicates that Cu2+, Cr2+, Zn2+ and Mg2+ the carboxylic group is employed as coordinative site for all compounds as a metal-ligand coordinative bond. As a general behavior, it is verified that the coordination compound thermal stability (considering the release of captopril molecules, not the release of water molecules) is affected by the metal cation radius: minor radius is associated with higher thermal stability, probably due to a higher metal-captopril bond dissociation enthalpy.
Abstract：In this work, we have reported the synthesis and spectroscopic characterization of captopril (Cap) coordination compounds: Cu(Cap)·2H2O, Cr(Cap)·H2O, Zn(Cap)·3H2O and Mg(Cap)4. Herein, it is worthily mentioned that the FTIR spectroscopic technique was employed to recognized the nature of coordination between captopril ligand and copper, chromium, zinc and magnesium(Ⅱ) metal ions. In view of the infrared spectroscopic tool, the copper(Ⅱ) metal ion coordinated toward captopril drug ligand through sulfur atom of SH group dependent on the absent of stretching vibration band of —SH. Based on this result, the stretching motion of νa(COO) shifts clearly indicates that Cu2+, Cr2+, Zn2+ and Mg2+ the carboxylic group is employed as coordinative site for all compounds as a metal-ligand coordinative bond. As a general behavior, it is verified that the coordination compound thermal stability (considering the release of captopril molecules, not the release of water molecules) is affected by the metal cation radius: minor radius is associated with higher thermal stability, probably due to a higher metal-captopril bond dissociation enthalpy.
基金资助: The Deanship of Scientific Research at Princess Nourah bint Abdulrahman University, through the Research Groups Program Grant no. (RGP-1440-0003)
通讯作者:
Ahmed M. Naglah
引用本文:
Asma S. Al-Wasidi, Nawal M. Al-Jafshar, Amal M. Al-Anazi, Ahmed M. Naglah, Robson F. de Farias, Claudio Airoldi, Moamen S. Refat. Synthesis, Spectroscopic Characterization and Thermogravimetric Analysis of Cr(Ⅱ), Cu(Ⅱ), Zn(Ⅱ) and Mg(Ⅱ), Captopril Coordination Compounds[J]. 光谱学与光谱分析, 2020, 40(02): 661-664.
Asma S. Al-Wasidi, Nawal M. Al-Jafshar, Amal M. Al-Anazi, Ahmed M. Naglah, Robson F. de Farias, Claudio Airoldi, Moamen S. Refat. Synthesis, Spectroscopic Characterization and Thermogravimetric Analysis of Cr(Ⅱ), Cu(Ⅱ), Zn(Ⅱ) and Mg(Ⅱ), Captopril Coordination Compounds. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(02): 661-664.
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