Application of the SIMCA Method to Cancer Diagnosis with Fourier-Transform Infrared Spectroscopy
LI Qing-bo1, YANG Li-min1, LING Xiao-feng2, WANG Jian-sheng3, ZHOU Xiao-si2, SHI Jing-sen3, WU Jin-guang1*
1. The State Key Laboratory of Rare Earth Materials and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China 2. Department of Surgery, Third Hospital, Peking University, Beijing 100083, China 3. Department of Oncology Surgery, the First Hospital of Xi'an Jiaotong University, Xi'an, 710061, China
Abstract：Early detection of cancer with mid-IR spectroscopy is a focal topic in the biomedical engineering field. A method was investigated for the detection of malignant tissues with Fourier Transform Infrared spectroscopy (FTIR) and chemometrics method of pattern recognition. Spectral pretreatment and wavelength range selection were studied to improve the classification effect of soft independent modeling of class analogy (SIMCA). To distinguish the malignant tissues from normal ones, sixty-three stomach tissue samples were investigated in this paper. Forty samples were chosen randomly as calibration set and the rest twenty-three samples as predicting set. The correctness of classification was 91%, which was satisfactory. This approach was proved to be a reliable and practicable method for cancer diagnosis. Benign and malignant tissues can be identified by the combination of FTIR spectroscopy and chemometrics, which is able to be developed as a rapid diagnosis method of cancer.
李庆波1，杨丽敏1，凌晓锋2，王健生3，周孝思2，石景森3，吴瑾光1* . SIMCA法在中红外癌症检测技术中的应用 [J]. 光谱学与光谱分析, 2004, 24(04): 414-417.
LI Qing-bo1, YANG Li-min1, LING Xiao-feng2, WANG Jian-sheng3, ZHOU Xiao-si2, SHI Jing-sen3, WU Jin-guang1* . Application of the SIMCA Method to Cancer Diagnosis with Fourier-Transform Infrared Spectroscopy . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2004, 24(04): 414-417.
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