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A Review of Structural Characterization and Detection Methods of Glycated Proteins in Food Systems |
ZHANG Peng1, 3, YANG Yi-fan1, WANG Hui1, TU Zong-cai1, 2, SHA Xiao-mei2, HU Yue-ming1* |
1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
2. National R&D Center for Freshwater Fish Processing and Engineering Research Center for Freshwater Fish High-Value Utilization of Jiangxi Province, Jingxi Normal University, Nanchang 330022, China
3. Foodmate Limited Company, Jiujiang 332100, China
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Abstract Proteins and sugars are important components of food. During food processing, storage and transportation, the amino group of protein molecules is easily combined with the carbonyl group of reducing sugar through covalent bonds, and the glycation reaction occurs. Maillard reaction-based glycation includes three stages: the early stage, the middle stage and the advanced stage. The glycation reaction modifies the main or side chains of proteins, changes the structure, static charge and hydrophobicity of proteins, and affects the chemical activities of the main and side chain groups of proteins, thus changing the physicochemical properties of proteins, including improving the emulsifying, foaming, gel and other functional properties, enhancing the antioxidant and other nutritional properties, while reducing the sensitization and enhancing the antibacterial and storage properties. It is very common and important in food processing, storage and transportation. The changes in protein structure during the reaction are the important causes of the alteration of nutritional and functional properties. In recent years, chemical analysis (free amino content and surface hydrophobicity determination, etc.), spectrometry (ultraviolet spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy, etc.), chromatography (circular dichroism, size-exclusion high-performance liquid chromatography, etc.), mass spectrometry (matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS), liquid chromatography-electrospray tandem mass spectrometry (LC-MS2), etc.) and other techniques have been explored to analyze the structural changing rules of protein during glycation reaction, playing the important roles in the mechanism study of glycation reaction as well as regulation of glycation degree and nutritional and functional properties of glycation products. In particular, the emergence and mature application of orbital ion trap mass spectrometry (LC-Orbitrap-MS2), Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR-MS2), hydrogen-deuterium exchange Fourier transform ion cyclotron resonance mass spectrometry (HDX-FTICR-MS2), and other technologies have made the research on glycation sites more in-depth. These technologies make it possible to reveal the mechanism of protein glycation reaction by quantifying the number of bonded sugar molecules and the degree of glycation substitution at each reaction site. This study reviewed characterization and detection methods for the protein glycation degree, primary, secondary and tertiary protein structures and functional group structure. This study aims to provide a reference for the deep research of protein glycation reaction and its application in food processing.
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Received: 2022-05-07
Accepted: 2022-07-26
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Corresponding Authors:
HU Yue-ming
E-mail: huyueming@ncu.edu.cn
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[1] XU Cai-hong, WANG Jin-mei, YAO Yu-jing, et al(许彩虹, 王金梅, 姚玉静, 等). Modern Food Science & Technology(现代食品科技), 2017, 33(8): 306.
[2] FENG Yan-ying, MU Dai-chen, QI Wen-lei, et al(冯燕英, 牟代臣, 祁文磊, 等). Food & Machinery(食品与机械), 2019, 35(2): 190.
[3] Wang X, Tu Z, Ye Y, et al. Journal of Agricultural and Food Chemistry, 2021, 69(24): 6850.
[4] Oliveira F C D, Coimbra J S D R, Oliveira E B D, et al. Critical Reviews in Food Science and Nutrition, 2016, 56(7): 1108.
[5] Chen W, Shao Y, Wang Z, et al. Food Chemistry, 2022, 372: 131308.
[6] Zhang M, Tu Z, Liu J, et al. Journal of Food Biochemistry. 2021, 45(1): e13539.
[7] Bu D, Tu Z, Wang H, et al. Food Chemistry, 2022, 374: 131616.
[8] Tu Z, Hu Y, Wang H, et al. Journal of Food Science and Technology, 2015, 52(3): 1453.
[9] Huang X, Tu Z, Xiao H, et al. Food Research International, 2012, 48(2): 866.
[10] SONG Qi-dong, TU Zong-cai, WANG Hui, et al(宋启东, 涂宗财, 王 辉, 等). Food & Machinery(食品与机械), 2018, 34(5): 1.
[11] FENG Yu-chao, WANG Chang-yuan, LI Yu-qiong, et al(冯玉超, 王长远, 李玉琼, 等). Journal of Chinese Institute of Food Science and Technology(中国食品学报), 2019, 19(7): 99.
[12] Jorge C A, Maria M L, Marcelo O V. Biopolymers, 2015, 103(10): 574.
[13] GUO Wei-bo, ZHAO Yan, XU Ming-sheng, et al(郭蔚波, 赵 燕, 徐明生, 等). Food Science(食品科学), 2019, 40(1): 327.
[14] CHENG Kai-li, HU Zhi-he, ZHAO Xu-fei, et al(程凯丽, 胡志和, 赵旭飞, 等). Journal of Dairy Science and Technology(乳业科学与技术), 2019, 42(6): 34.
[15] Liu G, Liu J, Tu Z, et al. Innovative Food Science and Emerging Technologies, 2018, 47: 286.
[16] Hu Y, Guo H, Wang H, et al. Food Chemistry, 2021, 342: 128340.
[17] Wang X, Ye Y, Tu Z, et al. LWT—Food Science and Technology, 2021, 139: 110506.
[18] Wang X, Ye Y, Tu Z, et al. Journal of Agricultural and Food Chemistry, 2021, 69(12): 3741.
[19] Xu Y, Zhao Y, Wei Z, et al. Food Hydrocolloids, 2020, 105: 105852.
[20] ZHOU Yang-ying, ZHENG Hong-li, YANG Wen-yu, et al(周洋莹, 郑红莉, 杨文钰, 等). Food and Fermentation Industries(食品与发酵工业), 2020, 46(1): 118.
[21] Xu D, Li L, Wu Y, et al. Ultrasonics Sonochemistry, 2020, 63: 104910.
[22] Liao Z, Ye Y, Wang H, et al. Journal of Agricultural and Food Chemistry, 2018, 66(41): 10693.
[23] Zhang Q, Tu Z, Xiao H, et al. Food and Bioproducts Processing, 2014, 92: 30.
[24] Hu Y, Chen H, Xiao L, et al. LWT—Food Science and Technology, 2019, 116: 108560.
[25] Liu G, Li W, Qin X, et al. Food Hydrocolloids, 2020, 101: 105503.
[26] Wang H, Sun Q, Tan J, et al. Food Chemistry, 2020, 318: 126519.
[27] ZHANG Yong, SHEN Bing-quan, QIN Wei-jie, et al(张 勇, 沈丙权, 秦伟捷, 等). Chinese Bulletin of Life Sciences(生命科学), 2018, 30(4): 480.
[28] Zhang Q, Tu Z, Wang H, et al. Journal of Agricultural and Food Chemistry, 2014, 62: 2522.
[29] Zhang Y, Xie X, Zhan X, et al. Journal of Proteomics, 2018, 170: 14.
[30] Bilan V, Leutert M, Nanni P, et al. Analytical Chemistry, 2017, 89(3): 1523.
[31] Yang Y, Liu G, Wang H. Journal of Agricultural and Food Chemistry, 2019, 67: 3096.
[32] Liu J, Chen W, Shao Y, et al. Food Chemistry, 2020, 310: 125853.
[33] QI Bao-kun, ZHAO Cheng-bin, JIANG Lian-zhou, et al(齐宝坤, 赵城彬, 江连洲, 等). Journal of Chinese Institute of Food Science and Technology(中国食品学报), 2018, 18(9): 53.
[34] Hu B, Wang K, Han L, et al. Food Hydrocolloids, 2020, 102: 105602.
[35] Shao Y, Zhang Y, Zhu M, et al. International Journal of Biological Macromolecules, 2020, 164: 1527.
[36] REN Meng-ke, BU Guan-hao, ZUO Ying-xin(任孟珂, 布冠好, 左颖昕). Food Research and Development(食品研究与开发), 2020, 41(6): 6.
[37] Hu Y, Wang L, Li Z. Journal of Cereal Science, 2017, 76: 222.
[38] Wang C, Li J, Li X, et al. Food Hydrocolloids, 2020, 99: 105356.
[39] LI Liang, ZHOU Yan, TENG Fei, et al(李 良, 周 艳, 滕 飞, 等). Transactions of the Chinese Society for Agricultural Machinery(农业机械学报), 2019, 50(8): 372.
[40] Zhao D, Xu D, Sheng B, et al. Food Hydrocolloids, 2020, 98: 105264.
[41] Yang W, Tu Z, Wang H, et al. Journal of Agricultural and Food Chemistry, 2017, 65(36): 8018.
[42] GE Wei, LI Xiao-dong, QU Jia-lin, et al(葛 伟, 李晓东, 曲佳林, 等). Journal of Chinese Institute of Food Science and Technology(中国食品学报), 2018, 18(2): 125.
[43] Du P, Tu Z, Wang H, et al. Journal of Agricultural and Food Chemistry, 2020, 68(39): 10586.
[44] Zhang L, Xu L, Tu Z, et al. Food Chemistry, 2020, 309: 125667.
[45] XIE Ya-wen, TU Zong-cai, ZHANG Lu, et al(谢雅雯, 涂宗财, 张 露, 等). Food and Fermentation Industries(食品与发酵工业), 2018, 44(10): 110.
[46] Xi C, Kang N, Zhao C, et al. Food Bioscience, 2020, 33: 100507.
[47] Wang P, Wang W, Chen C, et al. International Journal of Biological Macromolecules, 2020, 148: 761.
[48] Lu Y, Li S, Xu H, et al. Journal of Agricultural and Food Chemistry, 2018, 66(37): 9794.
[49] Zhang L, Lu Y, Ye Y, et al. Journal of Agricultural and Food Chemistry, 2019, 67(1): 236.
[50] Cardoso J C, Albuquerque R L C, Padilha F F, et al. Journal of Thermal Analysis and Calorimetry, 2011, 104(1): 249.
[51] Sha X, Tu Z, Liu W, et al. Food Hydrocolloids, 2014, 36: 173.
[52] Ghassan F M, Franz J S, Clemens K, et al. Food Chemistry, 2018, 245: 761.
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