| 光谱学与光谱分析 |
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| New Photosensitiser 5-ALA-GNPs for Photodynamic Therapy and Its Spectral Analysis |
| YAO Cui-ping1, WANG Si-jia1, YANG Yang1, HAN Yu-long1, 2, XU Hao1, ZENG Wei-hui3, ZHANG Zhen-xi1* |
1. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
2. Biomedical Engineering and Biomechanics Center, School of Aerospace, Xi’an Jiaotong University, Xi’an 710049, China
3. Department of Dermatology, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710061, China |
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Abstract A novel strategy by means of poly diallyl dimethylammonium chloride (PDDA) was used to make highly mono-dispersed positively charged gold nanoparticles, and 5-ALA was immobilized onto the gold nanoparticles through electrostatic interaction. The conjugation of 5-aminolevulinic acid (5-ALA) and gold nanopartilces were characterized by the integrated tools of resonance Rayleigh scattering (RRS), UV-Vis absorption spectra, transmission electron microscopy (TEM) and laser light scattering. The results demonstrated that 5-ALA can be attached onto positively charged gold nanoparticles. This new photosensitizer is significant for enhancing PDT efficacy clinically.
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Received: 2012-04-07
Accepted: 2012-07-25
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Corresponding Authors:
ZHANG Zhen-xi
E-mail: zxzhang@mail.xjtu.edu.cn
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