Abstract：To prepare the non-covalent molecularly imprinted polymers (MIPs) with good adsorption properties，the degree of interaction is important factor between the template molecule and functional monomer before polymerization. The correlative research has been reported less. In the present paper, UV combined with infrared spectra was applied to study intermolecular interaction of the template molecule and functional monomer. andrographolide was used as the template molecule, acrylamide (AM) as the functional monomer in the three kinds of solvents, namely acetonitrile, tetrahydrofuran and ethyl acetate. The experimental results showed that the UV absorption peaks at 224 nm exhibited blue-shift of 5 nm, and the absorption peak increased for andrographolide and AM in acetonitrile solvent. In IR spectra, the O—H stretching vibration was also blue-shifted by nearly 8 cm-1, while the N—H stretching vibration of blue shift was about 6 cm-1. The data showed that the strong interaction of blue-shifted hydrogen bonds generated between the molecules of andrographolide and AM. And intermolecular interaction was very weak in other two solvents. It is obvious that the stronger the intermolecular interaction, the greater the spectroscopy changes, the better the selectivity of identification points, and thus the better the adsorption properties of MIPs are.
尹小英，衷友泉，江一帆，罗永明* . 分子印迹聚合反应中功能单体与模板分子间作用力的光谱分析[J]. 光谱学与光谱分析, 2010, 30(08): 2211-2214.
YIN Xiao-ying, ZHONG You-quan, JIANG Yi-fan, LUO Yong-ming* . The Spectroscopy Analysis of Intermolecular Interaction Between the Template Molecule and Functional Monomer Before Polymerization . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2010, 30(08): 2211-2214.
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