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光谱学与光谱分析  2015, Vol. 35 Issue (02): 502-506    DOI: 10.3964/j.issn.1000-0593(2015)02-0502-05
  光谱学与光谱分析 |
Selective Determination of Itraconazole in the Presence of Its Oxidative Degradation Product by A New Spectrophotometric Method
Nesrine T. Lamie
Cairo University, Faculty of Pharmacy, Department of Analytical Chemistry, Kasr El-Aini Street, ET 11562, Cairo, Egypt
Selective Determination of Itraconazole in the Presence of Its Oxidative Degradation Product by A New Spectrophotometric Method
Nesrine T. Lamie
Cairo University, Faculty of Pharmacy, Department of Analytical Chemistry, Kasr El-Aini Street, ET 11562, Cairo, Egypt
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摘要A simple, specific, accurate and precise spectrophotometric stability indicating method is developed for determination of itraconazole in the presence of its oxidative degradation product and in pharmaceutical formulations. A newly developed spectrophotometric method called ratio difference method by measuring the difference in amplitudes between 230 and 265 nm of ratio spectra. The calibration curve is linear over the concentration range of 5~25 μg·mL-1 with mean percentage recovery of 99.81±1.002. Selective quantification of itraconazole, singly in bulk form, pharmaceutical formulations and in the presence of its oxidative degradation product is demonstrated. The results have been statistically compared with a pharmacopeial method.
关键词:Itraconazole;Stability indicating;Ratio difference;Spectrophotometry
Abstract:A simple, specific, accurate and precise spectrophotometric stability indicating method is developed for determination of itraconazole in the presence of its oxidative degradation product and in pharmaceutical formulations. A newly developed spectrophotometric method called ratio difference method by measuring the difference in amplitudes between 230 and 265 nm of ratio spectra. The calibration curve is linear over the concentration range of 5~25 μg·mL-1 with mean percentage recovery of 99.81±1.002. Selective quantification of itraconazole, singly in bulk form, pharmaceutical formulations and in the presence of its oxidative degradation product is demonstrated. The results have been statistically compared with a pharmacopeial method.
Key words:Itraconazole;Stability indicating;Ratio difference;Spectrophotometry
收稿日期: 2014-05-04     修订日期: 2014-09-17    
中图分类号:  O657.3  
通讯作者: Nesrine T. Lamie     E-mail: nesrinelamie@hotmail.com
引用本文:   
Nesrine T. Lamie. Selective Determination of Itraconazole in the Presence of Its Oxidative Degradation Product by A New Spectrophotometric Method[J]. 光谱学与光谱分析, 2015, 35(02): 502-506.
Nesrine T. Lamie. Selective Determination of Itraconazole in the Presence of Its Oxidative Degradation Product by A New Spectrophotometric Method. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2015, 35(02): 502-506.
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https://www.gpxygpfx.com/CN/10.3964/j.issn.1000-0593(2015)02-0502-05      或      https://www.gpxygpfx.com/CN/Y2015/V35/I02/502