光谱学与光谱分析 |
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Quantitative Analysis for Levocetirizine Hydrochloride Tablets Based on NIR Spectroscopy |
WANG Qin1,2, LIU Ye-hai1*, GAO Min-guang3, ZHAO Min-jie3 |
1. Department of Otalaryngology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China 2. Department of Otalaryngology, Hefei Second People’s Hospital of Anhui Medical University, Hefei 230022, China 3. Key Laboratory of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, China |
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Abstract The aim of this study was to develop a quantitative analytical method to measure the effective components in the left cetirizine hydrochloride tablets using near infrared spectroscopy combining with a partial least square (PLS) analysis model. The method was internal cross-validated to determine the best wavelength range, spectral preprocessing methods and the optimal number of principal components. The concentration of validation set samples was predictable by PLS model. The RMSECV value was 0.276, and the R2 value was 0.974. Our study suggests that this model can be used for rapid quantitative analysis of left cetirizine hydrochloride tablets from different manufacturers.
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Received: 2015-07-27
Accepted: 2015-11-08
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Corresponding Authors:
LIU Ye-hai
E-mail: huaishui1981@163.com
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