| 光谱学与光谱分析 |
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| Rapid Detection of Residual Cyclohexanone in Disposable Medical Devices by Ultraviolet Photoionization Ion Mobility Spectrometry (UV-IMS) |
| LI Hu1,3, HAN Hai-yan1, NIU Wen-qi2, WANG Hong-mei1, HUANG Chao-qun1, JIANG Hai-he1, CHU Yan-nan1* |
1. Laboratory of Environmental Spectroscopy, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Center of Medical Physics and Technology, Hefei Institutes of Physics, Hefei 230031, China
2. School of Science, Anhui Agricultural University, Hefei 230036, China
3. Anhui University of Science and Technology, Huainan 232001, China |
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Abstract In the manufacture of disposable PVC medical devices, cyclohexanone is frequently used as an adhesive reagent, which can be released into the tube airspace or stored solution and thus may cause some adverse effects on patients in therapy. In this paper, an ultraviolet photoionization ion mobility spectrometry (UV-IMS) technique has been developed to detect cyclohexanone through monitoring the gas composition within a package of infusion sets. The concentrations of cyclohexanone were prepared by means of exponential dilution method, and the experiments show that the UV-IMS has a limit of detection at 15 ppb and its measurable linear dynamics range is over three orders of magnitude. The concentrations of cyclohexanone in three brands of infusion sets packages were determined to be 16.78, 17.59 and 46.69 ppm respectively. The UV-IMS is proposed as a tool for the quality control of medical devices to monitor illegal uses of chemical solvents like cyclohexanone.
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Received: 2010-10-28
Accepted: 2011-04-10
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Corresponding Authors:
CHU Yan-nan
E-mail: ychu@aiofm.ac.cn
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