光谱学与光谱分析 |
|
|
|
|
|
Study on Inclusion Complexes of β-Cyclodextrin with Zopiclone |
CHEN Yuan-yuan1,LIU Jia-jia1,TANG Ke-wen1,2 |
1. College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China 2. Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414000, China |
|
|
Abstract The inclusion complex formation of zopiclone with β-cyclodextrin was studied by using phase solubility method, and the formation constant for zopiclone -β-cyclodextrin was determined. The solubility of zopiclone and the formation constant were enhanced with the increase in β-cyclodextrin concentration and pH. The effect of temperature on the reaction was studied through thermodynamics, and the changes in entropy ΔS, enthalpy ΔH and free energy ΔG of the reaction were all negative, suggesting that the inclusion complexation is exothermic and can spontaneously occur by the balance of enthalpy driving and entropy opposing. The inclusion complex of zopiclone and β-cyclodextrin was prepared by a method of solidgrinding,Stable inclusion complex in solid state was characterized by IR spectra and DTA. Results showed that zopiclone-β-cyclodextrin conclusion complex could be formed, and β-cyclodextrin is a desirable solubilizer for zopiclone.
|
Received: 2007-10-08
Accepted: 2008-01-16
|
|
Corresponding Authors:
CHEN Yuan-yuan
E-mail: cyy622811@126.com
|
|
[1] Jeffrey N C, Rene H, Jennifer W, et al. Eur. J. Pharm.,2001, 415: 181. [2] HE Zhong-gui, TANG Xing, CHEN Xuan-fu, et al(何仲贵, 唐 星, 陈宣富, 等). J. Shenyang Pharm. Univ.(沈阳药科大学学报), 1998, 15:235. [3] SHI Jie-min, HE Zhong-gui, XING Nan, et al(施洁明, 何仲贵, 邢 楠, 等). J. Chin. Pharm.(中国药学杂志),2004, 39, 5:353. [4] SHUANG Shao-min, GUO Si-yuan, PAN Jing-hao, et al(双少敏, 郭祀远, 潘景浩, 等). Chin. J. Anal. Chem.(分析化学), 1998,26, 5:564. [5] Brewster M E, Simphins J M, Hora M S. J. Parent. Sci. Technol., 1989, 43:231. [6] Zhang Y L, Agbaria R A, Warner I M. Supramolecaler Chemistry, 1997, 8:309. [7] YAO Hong, WEI Tai-bao, XU Wei-xia, et al(姚 虹, 魏太保, 徐维霞, 等). Spectroscopy and Spectral Analysis(光谱学与光谱分析),2006,26(9): 1664. [8] Chowdary K P R, Reddy G K, Int. J. Pharm. Excip.,2002, 3:12. [9] Chowdary K P R, Reddy G K. Indian J. Pharm. Sci.,2002, 64:142. [10] Worthington M S, Glass B D, Penkler L J. J. Inclusion Phenom. Mol. Recognit. Chem., 1996,25:153. [11] Higuchi T, Connors K A. Advances in Analytical Chemistry and Instrumentation, 1965, 4:117. [12] Stavroula Piperaki, Maria Parissi-Poulou. Journal of Chromatography A, 1996, 729: 19. [13] SUN De-mei, WU Xue-fen, ZHANG Shu-ling(孙德梅, 武雪芬, 张淑玲). J. Anhui Agric. Sci.(安徽农业科学),2005, 33:596. |
[1] |
LUO Wei-ang1,2, CHENG Ling1, DAI Li-zong1, CHEN Xu-dong2, MAI Kan-cheng2, CHEN Yu-jie3*, LIAO Zheng-fu4*. Polymer Crystallization Dynamics Investigated by Synchronous Scanning Spectrum[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2014, 34(09): 2320-2326. |
[2] |
SHEN Wen1*,ZHANG Guang-hua2,GUO Ning2,LI Yun-tao2 . Study on the Inclusion Compound of Avermectin by Infrared Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2014, 34(05): 1201-1205. |
[3] |
WANG Da-wei1,2, LIU Qi3,4, LIU Ming2, LIU Xiao-hui1* . The Preparation, Characterization and Ultraviolet Photodegradation of LNG-HP-β-CD [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2011, 31(03): 808-811. |
[4] |
DUAN Yun-qing1, 2, DUAN Zhi-qing1, MIN Shun-geng2*, XIONG Yan-mei2,DUAN Jia2, YE Sheng-feng2, WANG Dong2 . Spectrofluorimetric Study of Supramolecular Inclusion between Rodenticide Brodifacoum and β-Cyclodextrin and Application [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2010, 30(04): 1065-1069. |
[5] |
XIAO Yu-mei,WU Yan-hua,LIU Ji-ping,LI Yan-fang,LI Nan*,QIN Zhao-hai*. Study on the Molecular Recognization of Fungicide of Kresoxim-Methyl with β-cyclodextrin and Its Derivatives[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2008, 28(10): 2370-2374. |
[6] |
TONG Xiao-qing1,2,Lü Jian-quan1*,SUN Juan1,GONG Zhong-hong1 . Fluorescence and Visible Spectroscopic Studies on Interaction of β-Cyclodextrin-Thionine Inclusion Complex with DNA[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(12): 2538-2541. |
[7] |
QIU Hai-ou1,YANG Xiao-qiu2,YANG Ming3,XI Yong-qing1,TANG Zhi-yong1 . Enrichment of Triphenyltin in Water Samples by β-Cyclodextrin Cross-Linking Polymer and Determination by Hydride-Generation Atomic Fluorescence Spectrometry[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(04): 803-806. |
[8] |
YAO Hong, WEI Tai-bao, XU Wei-xia, ZHANG You-ming*. UV Spectroscopic Characterization of the Inclusion Interaction of β-Cyclodextrin and Sym-Diphenyl-Thiourea and Sym-Diphenyl-Urea[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(09): 1664-1667. |
[9] |
CHEN Xiao-yan, LIU Wan-yi*, ZHANG Jing. Study on the Characterization of β-Cyclodextrin-Diferrocenylenone Inclusion Complex and Micro-Environmental Effects[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(07): 1285-1289. |
[10] |
ZHANG Jing, LIU Wan-yi*,ZHANG Xia. Study on the Characterizations of β-Cyclodextrin-Benzoylferrocene- Thiosemicarbazone Inclusion Complex and Micro-Environmental Effects[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(03): 517-521. |
[11] |
ZHANG Jing, LIU Wan-yi*, ZHANG Xia. Study of the Characterization of β-Cyclodextrin-Acetylferrocene- Thiosemicarbazone Inclusion Complex and Micro-Environmental Effects [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(10): 1568-1572. |
[12] |
GUO Liang-qia, LIN Xu-cong, XIE Zeng-hong*, FU Yan-bin. Study on β-Cyclodexdrin Sensitizing Catalytic Kinetic Spectrophotometric Determination of Mn(Ⅱ) [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(10): 1662-1666. |
[13] |
ZHANG Li, SHE Shi-ke, GAO Feng, ZHOU Yun-you, ZHU Chang-qing,WANG Lun* . Highly Sensitive Spectrofluorimetric Determination of Trace Amounts of Chromium(Ⅵ) with Mono[6-o-(4-Aminobenzoic Acid)]-β-Cyclodextrin [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(07): 1103-1105. |
[14] |
LI Hong, HU Dao-dao, FANG Yu*, LIU Ya-ling . Spectroscopy Studies on the Interaction of Bis(p-Nitrophenyl) Esters and β-Cyclodextrin [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(02): 226-231. |
[15] |
FENG Guang-zhu,LU Kui,LI He-ping. Study on the Inclusion Complexation Interaction of β-Cyclodextrin and β-Carotene by UV-Vis Spectra [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2004, 24(09): 1099-1102. |
|
|
|
|