| 光谱学与光谱分析 |
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| FTIR Spectroscopic Explorations of Clinical Practice of Breast Cancer |
| LING Xiao-feng1, XU Zhi1, XU Yi-zhuang2*, LI Qing-bo2, ZHOU Su1, ZHANG Li2, ZHAO Hong-mei1, HOU Chun-sheng1, WANG Li-xin1, HOU Kuan-yong1, ZHOU Xiao-si1, WU Jin-guang2 |
1. Department of General Surgery, Third Hospital of Peking University, Beijing 100083, China
2. College of Chemistry, Peking University, Beijing 100871, China |
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Abstract The authors detected ten normal breast tissue samples and eight breast cancer samples by FTIR spectroscopy with an ATR probe. Nineteen variables of thirteen bands in the spectra were compared using standard statistic methods. The results demonstrated that bands of protein, lipid, carbohydrate, and nucleic acid from cancerous samples were significantly different from those from normal ones: (1) The relative intensity of N—H band increased and amide I band shifted to lower wave number significantly; (2)Symmetric and antisymmetric vibrations of —CH2 group, CO vibration, and relative intensity of (—CH2)n decreased; (3)The intensity of 1 160 cm-1 band was much weaker than that of 1 120 cm-1; (4)The band of PO or P—O—C shifted toward lower wave number. The authors believe that FTIR spectroscopy has a promising future in breast cancer diagnosis.
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Received: 2004-11-06
Accepted: 2004-12-28
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Corresponding Authors:
XU Yi-zhuang
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| Cite this article: |
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LING Xiao-feng,XU Zhi,XU Yi-zhuang, et al. FTIR Spectroscopic Explorations of Clinical Practice of Breast Cancer [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(02): 198-200.
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| URL: |
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https://www.gpxygpfx.com/EN/Y2005/V25/I02/198 |
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[4] WANG Jian-sheng, XU Yi-zhuang, SHI Jing-sen, ZHANG Li, DUAN Xiao-yi(王健生, 徐怡庄, 石景森，张 莉，段小艺). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2003, 23(15): 863.
[5] LI Qing-bo, YANG Li-min, LING Xiao-feng, WANG Jian-sheng, ZHOU Xiao-si et al(李庆波, 杨丽敏, 凌晓峰，王健生，周孝思等). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2004, 24(4): 414.
[6] SHEN Xue-chu(沈学础). The Fundamental Principle of FTIR Ｓpectrum. In: WU Jin-guang(Editor)(吴瑾光主编). The Techniques and Application of Modern Fourier Transform Infrared Spectroscopy(近代傅里叶变换红外光谱技术及应用). Beijing: Literature Press of Science and Technology(北京: 科学技术文献出版社)，1994.
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