光谱学与光谱分析 |
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Simultaneous Measurement of Muscle Energy Metabolism by MRS and Frequency-Domain NIR Spectroscopy |
ZHAO Jun1, DING Hai-shu1*, RUAN Man-qi1, KIME R2, CHANCE B2 |
1. Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China 2. Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA |
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Abstract The frequency-domain near-infrared spectrometry(NIRS) is capable of measuring the absolute absorption and reduced scattering coefficient of tissue noninvasively. This allows the quantitation of tissue hemoglobin concentration which reflects the balance between oxygen delivery and oxygen utilization of the skeletal muscle. Phosphorus magnetic resonance spectroscopy (31P-MRS) has become a gold standard of noninvasive measurement of human skeletal muscle metabolism. The rate of phosphocreatine (PCr) resynthesis during recovery is an indicator of the rate of oxidative metabolism. The purpose of the present study was the effect of lower intracellular pH (pHi) on PCr and oxygenation recovery. The preliminary results of plantar flexion experiment on a healthy male subject show that both PCr resynthesis and reoxygenation were very much prolonged by severe acidosis (pHi=6.42).
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Received: 2003-11-06
Accepted: 2004-03-16
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Corresponding Authors:
DING Hai-shu
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Cite this article: |
ZHAO Jun,DING Hai-shu,RUAN Man-qi, et al. Simultaneous Measurement of Muscle Energy Metabolism by MRS and Frequency-Domain NIR Spectroscopy [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(06): 861-865.
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URL: |
https://www.gpxygpfx.com/EN/Y2005/V25/I06/861 |
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