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| Beneficial Effects of Short-Wavelength Narrow Band Ultraviolet Irradiation Delivered Using an LED Device on Bone Metabolism in Rats |
| LI Yun-qi1, ZHANG Ning2, CHEN De-fu3, QIU Hai-xia1, ZENG Jing1, WANG Na5*, GU Ying1, 3, 4* |
1. The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
2. Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China
3. School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China
4. Precision Laser Medical Diagnosis and Treatment Innovation Unit, Chinese Academy of Medical Sciences, Beijing 100730, China
5. Hainan Hospital, Chinese PLA General Hospital, Sanya 572013, China |
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Abstract Background: Ultraviolet radiation is one of the key conditions to maintaining bone health, but it has not been paid enough attention to in the field of osteoporosis because of the wide traditional ultraviolet spectrum. With the development of LED technology, all kinds of narrowband LED spectra can be adjusted arbitrarily. Materials and methods: In this study, we established a newly designed LED device with a narrow band spectrum to investigate the effects of ultraviolet LED on bone metabolism, bone morphology and skin of osteoporotic rats. We have set up a total of unovariectomized rats (n=24) and ovariectomized rats (n=36). The unovariectomized rats were then divided into the sham operation group (Sham, n=12) and the detection model group (Sham, n=12). The ovariectomized rats were divided into either the LED irradiation group (LED, n=12), the no treatment group (OVX, n=12), or the detection model group (OVX, n=12). The LED Irradiation parameters (0.8 mW·cm-2, 1 000 s, twice a week).Results: Compared with the sham group, the expression of vitamin D mRNA, serum bone ALP, serum 25(OH)D3, and serum P1NP increased significantly, the serum PTH and serum TRAP decreased significantly. Conclusion: Our results show that irradiation with the new ultraviolet LED device can significantly increase the level of 25(OH)D3 in blood, promote bone formation and inhibit bone resorption without adverse effects on rat skin.
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Received: 2022-05-05
Accepted: 2022-07-04
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Corresponding Authors:
WANG Na, GU Ying
E-mail: 32772168@qq.com; guyinglaser@163.com
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[1] Chang B, Quan Q, Li Y, et al. Medical Science Monitor，2018, 24: 8758.
[2] Sozen T, Ozisik L, Calik Basaran N. European Journal of Rheumatology，2017, 4: 46.
[3] Wright N C, Looker A C, Saag K G, et al. Journal of Bone and Mineral Research，2014, 29: 2520.
[4] Hall S F, Wright N C, Wolinsky F D, et al. Archives of Osteoporosis，2018, 13.
[5] Kapinos K A, Fischer S H, et al. J. Am. Geriatr. Soc., 2018, 66: 2298.
[6] Tarrant S M, Balogh Z J. World Journal of Surgery，2020, 44: 1009.
[7] Al Anouti F, Taha Z, Shamim S，et al. Bone Reports，2019, 11.
[8] Body J J, Bergmann P, Boonen S, et al. Osteoporos. Int., 2010, 21: 1657.
[9] Kanis J A, Cooper C, Rizzoli R, et al. Osteoporos. Int., 2019, 30: 3.
[10] Miller P D, McCarthy E F. Semin Arthritis Rheum，2015, 44: 477.
[11] Lengfeld J, Buder-Bakhaya K, Goebeler M, et al. Dermatology，2016, 232: 117.
[12] Musette P, Kaufman J-M, Rizzoli R, et al. Therapeutic Advances in Musculoskeletal Disease，2010, 3: 31.
[13] Micic I, Jeon I H, Park S H, et al. Srp. Arh. Celok. Lek., 2013, 141: 615.
[14] Alexis Chuck J T, Brian Diffey. Subliminal Ultraviolet-B Irradiation for the Prevention of Vitamin D Deficiency in. 2001.
[15] Kift R, Rhodes L E, Farrar M D, et al. Int. J. Environ. Res. Public. Health., 2018, 15.
[16] Kneissl M, Rass J. Springer Series in Materials Science, 2016, 227.
[17] Zhang L, Guo Y N, Yan J C, et al. Optics Express, 2019, 27(4): 4917.
[18] Dong Peng, Yan Jianchang, Wang Junxi, et al. Applied Physics Letters, 2013，102(24): 4.
[19] Sun Xiaobin, Zhang Zhenyu, Anas Chaaban, et al. Optics Express, 2017，25(19): 23267.
[20] Minamikawa T, Koma T, Suzuki A, et al. Scientific Reports, 2021, 11(1).
[21] Levi, Kemal. J. Mech. Behav. Biomed. Mater., 2013, 28(Complete): 471.
[22] Hirayama H. Journal of Semiconductors，2019, 40.
[23] Pattison P M, Tsao J Y, Brainard G C, et al. Nature，2018, 563: 493.
[24] Sung Bae Park MDYJL, M S, et al. Bone Mineral Density Changes after Ovariectomy. 2010.
[25] Kalajian T A, Aldoukhi A, Veronikis A J, et al. Ultraviolet B Light Emitting Diodes (LEDs) Are More Efficient and Effective in Producing Vitamin D3 in Human Skin Compared to Natural Sunlight. Scientific Reports 2017, 7.
[26] A R Webb L K, Holick M F. Influence of Season and Latitude on the Cutaneous Synthesis of Vitamin D3 Exposure to Winter Sunlight in Boston and Edmonton Will Not Promote Vitamin D3 Synthesis in Human Skin，1988.
[27] Going C C, Alexandrova L, Lau K, et al. Breast Cancer Res. Treat.，2018, 167: 797.
[28] Bouxsein M L, Boyd S K, Christiansen B A, et al. J. Bone. Miner. Res., 2010, 25: 1468.
[29] Xian D, Gao X, Xiong X, et al. J. Photochem. Photobiol. B, 2017, 175: 73.
[30] Sakai S, Hongo H, Yamamoto T, et al. Calcif. Tissue. Int., 2019, 104: 251.
[31] Fan J, Li N, Gong X, He L. Clin. Chim. Acta, 2018, 477: 135.
[32] Dhanalakshmi S, Agarwal C, Singh R P, et al. J. Biol. Chem., 2005, 280: 20375.
[33] Barnkob L L, Argyraki A, Petersen P M, et al. Food Chem., 2016, 212: 386.
[34] Morita D, Nishida Y, Higuchi Y, et al. Journal of Photochemistry and Photobiology B: Biology，2016, 164: 256.
[35] HA Bischoff-Ferrari M B, F Gudat, UDürmüller, et al. Vitamin D Receptor Expression in Human Muscle Tissue Decreases With Age，2004.
[36] Li L, Wang Z. Adv. Exp. Med. Biol., 2018, 1086: 199.
[37] D’Souza C, Yuk H-G, Khoo G H, et al. Comprehensive Reviews in Food Science and Food Safety，2015, 14: 719.
[38] Pang Q, Lou D, Li S, et al. Adv. Sci. (Weinh), 2020, 7: 1902673.
[39] Chang B, Qiu H, Zhao H, et al. Med. Sci. Monit., 2019, 25: 8744.
[40] Felton S J, Cooke M S, Kift R, et al. Br. J. Dermatol., 2016, 175: 1320.
[41] Taniyama T, Saruta J, Mohammadzadeh Rezaei N, et al. Int. J. Mol. Sci., 2020, 21.
[42] Berry S D, Kiel D P, Colon-Emeric C. JAMA，2019, 321: 2231.
[43] Harvey N, Dennison E, Cooper C. Nat. Rev. Rheumatol., 2010, 6: 99.
[44] Reuben D B, Gazarian P, Alexander N, et al. J. Am. Geriatr. Soc., 2017, 65: 2733.
[45] A R Webb L K, Holick M F. Influence of Season and Latitude on the Cutaneous Synthesis of Vitamin D3: Exposure to Winter Sunlight in Boston and Edmonton Will Not Promote Vitamin D3 Synthesis in Human Skin，1988.
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