|
|
|
|
|
|
| Preparations and Spectroscopic Studies on the Three New Strontium(Ⅱ), Barium(Ⅱ), and Lead(Ⅱ) Carbocysteine Complexes |
| Samy M. El-Megharbel*, Moamen S. Refat |
| Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia |
|
|
|
|
Abstract Carbocisteine, also known as carbocysteine, is a mucolytic that reduces the viscosity of sputum and thus can be used to help relieve symptoms of chronic obstructive pulmonary disorder and bronchiectasis by allowing the sufferer to expel sputum more easily. A total of three new metal complexes of carbocysteine, HCcy with the metal ions Sr(Ⅱ), Ba(Ⅱ), and Pb(Ⅱ) have been successfully prepared in alkaline medium in situ H2O/CH3OH (50/50 w/w). The complexes obtained are characterized quantitatively and qualitatively by using micro elemental analysis, FTIR spectroscopy, UV-Vis spectroscopy, X-ray powder diffraction spectroscopy, 1H-NMR, and conductivity measurements. From the spectral study, all the synthesized Ccy complexes obtained as monomeric structure and the metals center moieties are six-coordinated except lead(Ⅱ) complex which existed as a four-coordinated respectively, suggesting formulas [Sr(Ccy)(H2O)2], [Ba(Ccy)(H2O)2] and [Pb(Ccy)] in neutral form. Beside, regarding both Sr(Ⅱ) and Ba(Ⅱ) complexes, the aquo groups are existed inside the coordination sphere. The infrared assignments reveal that HCcy ligand act as a bidentate ligand with the metal ions through oxygens of the deprotonated carboxylic COOH group. The 1H-NMR spectrum of the [Ba(Ccy)(H2O)2] complex has an absent of the proton of —COOH groups upon the deprotonated of carboxylic group.
|
|
Received: 2020-11-18
Accepted: 2021-03-06
|
|
|
|
Corresponding Authors:
Samy M. El-Megharbel
E-mail: samyelmegharbel@yahoo.com
|
|
[1] Bichona E, Sitthisacka P, Sérée-Vattiera L, et al. Food Chemistry, 2018，260：283.
[2] Manivannan M, Rajeshwaran K, Govindhan R, et al. Journal of Molecular Structure, 2017, 1144: 432.
[3] El-Megharbel S M, Hamza R Z, Refat M S. Chemico-Biological Interactions，2014，220：169.
[4] Refat M S. J. Mol. Struct.，2007，842(1-3)：24.
[5] Hannon M. J. Pure Appl. Chem.，2007，79：2243.
[6] Mehrotra R C. Metal Carboxylates; Academic Press Inc.: London, 1983.
[7] Rardin R L, Tolman W B, Lippard S J. New J. Chem.，1991 15：417.
[8] Zheng J P, Kang J, Huang S G, et al. Lancet，2008，371：2013.
[9] Rahman I, MacNee W. Curr. Opin. Pharmacol.，2012，12：256.
[10] Nakon R, Beadle E M, Angelici R J. J. Am. Chem. Soc., 1974, 96: 719.
[11] Brumas V, Venturini M, Filella M, et al. J. Inorg. Biochem., 1989, 37: 309.
[12] Cromer-Morin M, Scharff J P, Claude M, et al. Anal. Chim. Acta，1979，104：299.
[13] Deacon G B, Phillips R J. Coord. Chem. Rev., 1980，33：227.
[14] Nakamoto K. Infrared and Raman Spectra of Inorganic and Coordination Compounds. Wiely, New York, 1978. |
| [1] |
MA Fang1, HUANG An-min2, ZHANG Qiu-hui1*. Discrimination of Four Black Heartwoods Using FTIR Spectroscopy and
Clustering Analysis[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(06): 1915-1921. |
| [2] |
ZHANG Dian-kai1, LI Yan-hong1*, ZI Chang-yu1, ZHANG Yuan-qin1, YANG Rong1, TIAN Guo-cai2, ZHAO Wen-bo1. Molecular Structure and Molecular Simulation of Eshan Lignite[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(04): 1293-1298. |
| [3] |
WANG Fang-fang1, ZHANG Xiao-dong1, 2*, PING Xiao-duo1, ZHANG Shuo1, LIU Xiao1, 2. Effect of Acidification Pretreatment on the Composition and Structure of Soluble Organic Matter in Coking Coal[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(03): 896-903. |
| [4] |
HU Chao-shuai1, XU Yun-liang1, CHU Hong-yu1, CHENG Jun-xia1, GAO Li-juan1, ZHU Ya-ming1, 2*, ZHAO Xue-fei1, 2*. FTIR Analysis of the Correlation Between the Pyrolysis Characteristics and Molecular Structure of Ultrasonic Extraction Derived From Mid-Temperature Pitch[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(03): 889-895. |
| [5] |
YANG Jiong1, 2, QIU Zhi-li1, 4*, SUN Bo3, GU Xian-zi5, ZHANG Yue-feng1, GAO Ming-kui3, BAI Dong-zhou1, CHEN Ming-jia1. Nondestructive Testing and Origin Traceability of Serpentine Jade From Dawenkou Culture Based on p-FTIR and p-XRF[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(02): 446-453. |
| [6] |
HE Xiong-fei1, 2, HUANG Wei3, TANG Gang3, ZHANG Hao3*. Mechanism Investigation of Cement-Based Permeable Crystalline Waterproof Material Based on Spectral Analysis[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(12): 3909-3914. |
| [7] |
ZHOU Jing1,2, ZHANG Qing-qing1,2, JIANG Jin-guo2, NIE Qian2, BAI Zhong-chen1, 2*. Study on the Rapid Identification of Flavonoids in Chestnut Rose (Rosa Roxburghii Tratt) by FTIR[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(10): 3045-3050. |
| [8] |
Samy M. El-Megharbel*，Moamen S. Refat. In First Time: Synthesis and Spectroscopic Interpretations of Manganese(Ⅱ), Nickel(Ⅱ) and Mercury(Ⅱ) Clidinium Bromide Drug Complexes[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(10): 3316-3320. |
| [9] |
WANG Yi1, 2, LI Chang-rong1, 2*, ZHUANG Chang-ling1, 2. Study on Alumina/Lanthanum Oxide X-Ray Diffraction and Raman Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(08): 2480-2483. |
| [10] |
LI Huan-tong1, 2, CAO Dai-yong3*, ZHANG Wei-guo1, 2, WANG Lu4. XRD and Raman Spectroscopy Characterization of Graphitization Trajectories of High-Rank Coal[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(08): 2491-2498. |
| [11] |
YU Chun-mei, ZHANG Nan, TENG Hai-peng. Investigation of Different Structures of Coals Through FTIR and Raman Techniques[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(07): 2050-2056. |
| [12] |
YE Xu1, QIU Zhi-li1, 2*, CHEN Chao-yang3, ZHANG Yue-feng1. Nondestructive Identification of Mineral Inclusions by Raman Mapping: Micro-Magnetite Inclusions in Iridescent Scapolite as Example[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(07): 2105-2109. |
| [13] |
SUN Feng1, 2, YAN Qing-qing1, WANG Lu1, SUN Zhen-fei1. Study on the Conditions of Hydrothermal Synthesis of Chinese Purple BaCuSi2O6 and the Analysis of Its Products[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(07): 2284-2287. |
| [14] |
QU Li-guo1,2,3, LIU Jian-guo1, XU Liang1*, XU Han-yang1, JIN Ling1, DENG Ya-song1,2, SHEN Xian-chun1, SHU Sheng-quan1,2. Vehicle Exhaust Detection Method Based on Portable FTIR[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(06): 1751-1757. |
| [15] |
Samar O. Aljazzar. Spectroscopic Investigations for the Six New Synthesized Complexes of Fluoroquinolones and Quinolones Drugs With Nickel(Ⅱ) Metal Ion: Infrared and Electronic Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(06): 1976-1981. |
|
|
|
|
