光谱学与光谱分析 |
|
|
|
|
|
Synthesis of N-(Solanesylpiperazine-Alkyl)-9-Anthracenemethylamines and Its Interaction with DNA |
WANG Jian-hong,CHENG Peng-fei,SUN Xin-qi,ZHAO Jin,WANG Chao-jie* |
Lab of Natural Products and Medicines,College of Chemistry and Chemical Engineering,Henan University,Kaifeng 475001,China |
|
|
Abstract Two novel N-solanesylpiperazine triamines (4a,4b) were synthesized and their structures were characterized by 1H NMR,IR,MS,and elemental analysis. The preliminary in vitro tests revealed that the IC50 values of compound 4a and 4b on L1210 were 4.3 and 3.1 μmol respectively. The interaction of 4b with DNA was also investigated via UV and FL spectra with N1-(4-aminobutyl)-N4-(9-anthracenylmethyl) butane-1,4-diamine (5) as the reference compound. The results revealed that compound 5 could quench the fluorescence of DNA-EB system,while compound 4b had the opposite function. Further tests proved that the fluorescence of compound 5 and 4b could be both quenched by DNA. It was speculated that compound 4b,with the long chain and two tertiary nitrogens,interacted with DNA by the static attraction or was partially embedded into DNA,while compound 5 was typically inserted into DNA.
|
Received: 2006-03-08
Accepted: 2006-06-16
|
|
Corresponding Authors:
WANG Chao-jie
E-mail: wcjsxq@henu.edu.cn
|
|
Cite this article: |
WANG Jian-hong,CHENG Peng-fei,SUN Xin-qi, et al. Synthesis of N-(Solanesylpiperazine-Alkyl)-9-Anthracenemethylamines and Its Interaction with DNA[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(07): 1398-1402.
|
|
|
|
URL: |
https://www.gpxygpfx.com/EN/Y2007/V27/I07/1398 |
[1] Casero J R A,Woster P M. J. Med. Chem.,2001,44: 1. [2] Karigiannis G,Papaioannou D. Eur. J. Org. Chem.,2000,10: 1841. [3] WANG Jian-lin,FU Lian-chun,ZHOU Shi-wu,et al(王建林,付连春,周实武,等). Spectroscopy and Spectral Analysis(光谱学与光谱分析),2005,25(6): 912. [4] DU Jiang-yan,HUANG Xiao-hua,XU Fei,et al(杜江燕,黄晓华,徐 飞,等). Spectroscopy and Spectral Analysis(光谱学与光谱分析),2005,25(9): 1435. [5] YANG Ming(杨 铭). Journal of Beijing Medical University(北京医科大学学报),1998,30(2): 97. [6] Brissault B,Kichler A,Guis C,et al. Bioconjugate Chem.,2003,14: 581. [7] Andrew J Geall,Blagbrough I S. Tetrahedron,2000,56: 2449. [8] Sidorova T A,Nigmatov A G,Kakpakova E S. J. Med. Chem.,2002,45: 5330. [9] Wang C J,Delcros J G,Biggerstaff J,et al. J. Med. Chem.,2003,46: 2663. [10] WANG Chao-jie,SONG Jin-yong,ZHAO Jin(王超杰,宋金勇,赵 瑾). Chin. J. Org. Chem.(有机化学),2004,24: 1444. [11] PENG Jun-feng,LING Jian-ya,ZHANG Han-xing,et al(彭俊峰,凌建亚,张晗星,等). Spectroscopy and Spectral Analysis(光谱学与光谱分析),2004,24(7): 858. [12] HE Ji-xiang,JIANG Chong-qiu,GAO Ming-xia(贺吉香,江崇球,高明霞). Spectroscopy and Spectral Analysis(光谱学与光谱分析),2003,23(4): 755. |
[1] |
LEI Hong-jun1, YANG Guang1, PAN Hong-wei1*, WANG Yi-fei1, YI Jun2, WANG Ke-ke2, WANG Guo-hao2, TONG Wen-bin1, SHI Li-li1. Influence of Hydrochemical Ions on Three-Dimensional Fluorescence
Spectrum of Dissolved Organic Matter in the Water Environment
and the Proposed Classification Pretreatment Method[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2024, 44(01): 134-140. |
[2] |
GU Yi-lu1, 2,PEI Jing-cheng1, 2*,ZHANG Yu-hui1, 2,YIN Xi-yan1, 2,YU Min-da1, 2, LAI Xiao-jing1, 2. Gemological and Spectral Characterization of Yellowish Green Apatite From Mexico[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2024, 44(01): 181-187. |
[3] |
HAN Xue1, 2, LIU Hai1, 2, LIU Jia-wei3, WU Ming-kai1, 2*. Rapid Identification of Inorganic Elements in Understory Soils in
Different Regions of Guizhou Province by X-Ray
Fluorescence Spectrometry[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2024, 44(01): 225-229. |
[4] |
WANG Hong-jian1, YU Hai-ye1, GAO Shan-yun1, LI Jin-quan1, LIU Guo-hong1, YU Yue1, LI Xiao-kai1, ZHANG Lei1, ZHANG Xin1, LU Ri-feng2, SUI Yuan-yuan1*. A Model for Predicting Early Spot Disease of Maize Based on Fluorescence Spectral Analysis[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(12): 3710-3718. |
[5] |
CHENG Hui-zhu1, 2, YANG Wan-qi1, 2, LI Fu-sheng1, 2*, MA Qian1, 2, ZHAO Yan-chun1, 2. Genetic Algorithm Optimized BP Neural Network for Quantitative
Analysis of Soil Heavy Metals in XRF[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(12): 3742-3746. |
[6] |
SONG Yi-ming1, 2, SHEN Jian1, 2, LIU Chuan-yang1, 2, XIONG Qiu-ran1, 2, CHENG Cheng1, 2, CHAI Yi-di2, WANG Shi-feng2,WU Jing1, 2*. Fluorescence Quantum Yield and Fluorescence Lifetime of Indole, 3-Methylindole and L-Tryptophan[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(12): 3758-3762. |
[7] |
YANG Ke-li1, 2, PENG Jiao-yu1, 2, DONG Ya-ping1, 2*, LIU Xin1, 2, LI Wu1, 3, LIU Hai-ning1, 3. Spectroscopic Characterization of Dissolved Organic Matter Isolated From Solar Pond[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(12): 3775-3780. |
[8] |
LI Xiao-li1, WANG Yi-min2*, DENG Sai-wen2, WANG Yi-ya2, LI Song2, BAI Jin-feng1. Application of X-Ray Fluorescence Spectrometry in Geological and
Mineral Analysis for 60 Years[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(10): 2989-2998. |
[9] |
XUE Fang-jia, YU Jie*, YIN Hang, XIA Qi-yu, SHI Jie-gen, HOU Di-bo, HUANG Ping-jie, ZHANG Guang-xin. A Time Series Double Threshold Method for Pollution Events Detection in Drinking Water Using Three-Dimensional Fluorescence Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(10): 3081-3088. |
[10] |
MA Qian1, 2, YANG Wan-qi1, 2, LI Fu-sheng1, 2*, CHENG Hui-zhu1, 2, ZHAO Yan-chun1, 2. Research on Classification of Heavy Metal Pb in Honeysuckle Based on XRF and Transfer Learning[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(09): 2729-2733. |
[11] |
YE Zi-yi, LIU Shuang, ZHANG Xin-feng*. Screening of DNA Dyes for Colorimetric Sensing Via Rapidly Inducing Gold Nanoparticles Aggregation[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(09): 2805-2810. |
[12] |
JIA Yu-ge1, YANG Ming-xing1, 2*, YOU Bo-ya1, YU Ke-ye1. Gemological and Spectroscopic Identification Characteristics of Frozen Jelly-Filled Turquoise and Its Raw Material[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(09): 2974-2982. |
[13] |
YANG Xin1, 2, XIA Min1, 2, YE Yin1, 2*, WANG Jing1, 2. Spatiotemporal Distribution Characteristics of Dissolved Organic Matter Spectrum in the Agricultural Watershed of Dianbu River[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(09): 2983-2988. |
[14] |
CHEN Wen-jing, XU Nuo, JIAO Zhao-hang, YOU Jia-hua, WANG He, QI Dong-li, FENG Yu*. Study on the Diagnosis of Breast Cancer by Fluorescence Spectrometry Based on Machine Learning[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(08): 2407-2412. |
[15] |
ZHU Yan-ping1, CUI Chuan-jin1*, CHENG Peng-fei1, 2, PAN Jin-yan1, SU Hao1, 2, ZHANG Yi1. Measurement of Oil Pollutants by Three-Dimensional Fluorescence
Spectroscopy Combined With BP Neural Network and SWATLD[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(08): 2467-2475. |
|
|
|
|