Study for the Photon Propagation Properties in Biological Tissue Based on Frequency-Domain Near-Infrared Spectroscopy
HU Wen-yan1,3, LIU Hui1,3, WANG Yu-heng1,3, LI Jun-hui1,3, ZHANG Xiao-shuan2, WANG Zhong-yi1,3, ZHAO Long-lian1,3*
1. College of Information and Electrical Engineering, China Agricultural University, Beijing 100083, China
2. Beijing Laboratory of Food Quality and Safety, Beijing 100083, China
3. Modern Precision Agriculture System Integration Research Key Laboratory, Ministry of Education, Beijing 100083, China
Abstract:Based on the theory of photon radiative transfer in biological tissue and Feng model, we applied frequency-domain near-infrared spectroscopy to study the position changes of the little ball in the biological tissue how to influence the intensity and phase of emergent light, and learn if there are regularities of the intensity and phase changing. A simulation experiment was designed using the milk as biological tissue and a little ball as the tissue lesions. The ball was fixed to a thin rod and allowed to be moved up and down in the milk. At every step of the little ball, data of AC, DC and Phase were collected and stored in files that were then converted to waveform in Matlab. According to the results of the experiment, the variation trend of the AC and DC plot were displayed same, and the phase plot does indeed display the biphasic behavior. The valleys of the AC, DC and Phase plots were all offset to the right with the increasing of distance between light sources and detectors. And the greater degree of ball deviating from the light sources and detectors, the smaller effects that the ball acted on intensity and phase detected. With the discussion of the results, we could finally delve into the heart of this set of experiments, which was to show that the photons transmission was confirmed concerning the theory of radiative transfer. This research also established foundation to detect the tissue parameters and locate the position of tissue lesions by frequency-domain near-infrared spectroscopy.
胡文雁,刘 慧,王宇恒,李军会,张小栓,王忠义,赵龙莲. 频域近红外光谱法研究生物组织内部光子传输特性[J]. 光谱学与光谱分析, 2017, 37(04): 1074-1080.
HU Wen-yan, LIU Hui, WANG Yu-heng, LI Jun-hui, ZHANG Xiao-shuan, WANG Zhong-yi, ZHAO Long-lian. Study for the Photon Propagation Properties in Biological Tissue Based on Frequency-Domain Near-Infrared Spectroscopy. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2017, 37(04): 1074-1080.
[1] Sakami M, Mitra K, Vo-Dinh T. Optics Letters, 2007, 27(5): 336.
[2] Handapangoda C C, Premaratne M, Paganin D M, et al. Optics Express, 2008, 16(22): 17792.
[3] Stefan Hartmann, Matthias Moschall, Oliver Schafer, et al. Optics and Photonics Journal, 2015, 5(2): 33.
[4] DING Hai-shu, WANG Feng, SU Chang, et al(丁海曙,王 峰,苏 畅,等). Journal of Tsinghua University·Science and Technology(清华大学学报·自然科学版), 1999, 39(9): 5.
[5] HOU Rui-feng, HUANG Lan, WANG Zhong-yi, et al(侯瑞锋,黄 岚,王忠义,等). Transactions of the Chinese Society of Agricultural Engineering(农业工程学报), 2005, 21(9): 12.
[6] SUN Mei-xiu, KANG Mei-ling, LI Ying-xin, et al(孙美秀,康美玲,李迎新,等). International Journal of Biomedical Engineering(国际生物医学工程杂志), 2012, 35(1): 14.
[7] ZHANG Yong, CHEN Bin, LI Dong(张 永,陈 斌,李 东). Chinese Journal of Lasers(中国激光), 2015, 42(1): 162.
[8] Li X D, Yodh A G, Chanee B. Optics Letters, 1997, 22(8): 573.
[9] Hamaoka Takafumi, McCully Kevin K, Niwayama Masatsugu, et al. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2011, 369(1955): 4591.
[10] Gratton G, Fabiani M. Human Brain Mapping, 2001, 13(1): 13.
[11] Parks N A, Mazzi C, Tapia E, et al. Neuropsychologia, 2015, 78(11): 153.
[12] Chiarelli A M, Maclin E L, Low K A, et al. Journal of Biomedical Optics, 2016, 21(3): 1.
[13] WU Gui-ling, LUO Qing-ming, ZENG Shao-qun, et al(吴龟灵,骆清铭,曾绍群,等). Journal of Optoelectronics·Laser(光电子·激光), 2001, 12(3): 323.
[14] Feng S C, Zeng F A, Chance B. Applied Optics, 1995, 34(19): 3826.
[15] Gratton G, Brumback C R, Gordon B A, et al. Neuroimage, 2000, 11(5): 491.
[16] Shepherd J A, Blake G M. Journal of Clinical Densitometry, 2007, 10(4): 349.