YAN Xun-ling1，DONG Rui-xin1, 2，WANG Qiu-guo1，CHEN Shuang-feng3，ZHANG Zong-wang4，ZHANG Xue-jun4，ZHANG Lei4
1. School of Physics Ｓｃｉｅｎｃｅ ａｎｄ Ｉｎｆｏｒｍａｔｉｏｎ Ｅｎｇｉｎｅｅｒｉｎｇ，Liaocheng University, Liaocheng 252059，Ｃｈｉｎａ 2. Ｓｃｈｏｏｌ ｏｆ Physics Ｅｌｅｃｔｒｏｎｉｃｓ，University of Electronic Science and Technology of China, Chengdu 610054，Ｃｈｉｎａ 3. Central Laboratory of Liaocheng People's Ｈospital, Liaocheng 252000，Ｃｈｉｎａ 4. Surgery of Liaocheng Pepole's Hospital, Liaocheng 252000，Ｃｈｉｎａ
Abstract：Raman spectra of normal and cancer cell from breast cancer patients are presented. It is reported that all of the Raman lines become weak. The intensitｉｅｓ of Raman lines 782 ａｎｄ 1 084 cm-1 of DNA phosphate group and 1 155 ａｎｄ 1 262 cm-1 of deoxyribose-phosphate decrease. The spectral lines 812 cm-1of A-type DNA and 979 ａｎｄ 668 cm-1 disappear, ａｎｄ the 905 cm-1 peak is shifted to lower frequency by 6 cm-1. This means that ｔｈｅ phosphate backbone of DNA is destroyed to a certain extent and ｔｈｅ fissipariｔｙ of cancer cell can’t be controlled effectively. In addition, the authors found a kind of Raman line 960 cm-1 concernｉｎｇ calcifiｃａｔｉｏｎ and sclerosis of cancer cell. The results indicate that Raman spectra may offer the experiment basis for the cancer diagnosis and treatment.
[1] Fabian Ｈ, Jackson Ｍ, Murphy Ｌ ｅｔ ａｌ. Biospectroscopy, 1995, 1: 37. [2] GAO Xiao-ling(高小玲), Ian S Butler，Richard K Ｒemer. Acta Laser Biology Sinica(激光生物学报)，1998, 7(1)：22. [3] SUN Chuan-wen, ＸＵ Yi-zhuang, ＳＵＮ Kai-hua，WU Qi-guang, LI Wei-hong et al(孙传文，徐怡庄，孙开华，吴奇光，李维红等). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，1996, 16(5)：22. [4] ＸＵ Yi-ming, ＺＨＡＮＧ Zhi-yi，ＺＨＡＮＧ Wei(许以明，张志义，张 伟). Science in China C(中国科学C), 1998, 28(5): 417. [5] ＸＵ Yi-ming, ＹＡＮＧ Hong-ying，ＺＨＡＮＧ Zhi-yi(许以明，杨红英，张志义). Science in China C(中国科学C), 1999, 29(2): 138. [6] ＸＵ Yi-ming, ＺＨＡＮＧ Zhi-yi，ＸＵ Guo-rui(许以明，张志义，许国瑞). Chinese Science Bulletin(科学通报) , 1989, 34(19): 1500. [7] ＬＩ Wei-hong, ＸＵ Yi-zhuang, ＷＥＮＧ Shi-fu et al(李维红，徐怡庄，翁诗甫等). Chinese Journal of Light Scattering(光散射学报)，1998，10(3)：114. [8] Nicholas Stone, Catherine Kendall, Neil Shepherd et al. Journal of Raman Spectroscopy, 2002, 33: 654. [9] Liu C H, Das B B, Glassman S et al. J. Photochem. Photobiol. B: Biol.，1992, 16:187. [10] Redd D C B, Feng Z C, Yue K T et al. Appl. Spectroso., 1992, 47: 787.
