1. School of Public Health, Peking University, Beijing 100083, China 2. Laboratory of Biometallomics, Center of Medical & Health Analysis, Peking University, Beijing 100083, China 3. Haidian District of Beijing Centers for Disease Prevention and Control, Beijing, 100037, China
Abstract：The research studied the influence of matrix effect on the determination of lead concentration and isotope ratio through simulating blood matrix, and its correction by common analyte internal standardization (CAIS) method. The experiment results showed that CAIS method was suitable for the multi-element-matrix. The relative errors between the determined and the true concentration values are 20%(without correction), 8%(by conventional internal reference correction) and 2% (by CAIS correction), respectively. Otherwise, the influence of matrix effect and its correction for isotope ratio determination are not that obvious. Similarity of the mass number and properties between internal reference and analyte elements seems not important for CAIS correction, since very close correction results were obtained by using Tl and Dy as internal reference elements. Besides, correction results are not affected by different matrix dilution. Reliability and practicality of CAIS were proved by bovine blood standard material determination.
Key words：Common analyte internal standardization;Matrix effect;Lead;Isotope ratio
曾静1,王晓燕1，2,刘虎生1,敦哲3,翟蕾3,王京宇1，2* . CAIS法校正ICP-MS测定血铅浓度及同位素比值基体效应的研究[J]. 光谱学与光谱分析, 2007, 27(02): 374-377.
ZENG Jing1,WANG Xiao-yan1, 2,LIU Hu-sheng1,DUN Zhe3,ZHAI Lei3,WANG Jing-yu1, 2* . CAIS Correction for Blood Matrix Effect on Determination of Lead Concentration and Isotope Ratio by ICP-MS. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(02): 374-377.
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