| 光谱学与光谱分析 |
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| Preparation of and Study on Magnetic Resonance Imaging Performance of Metal Porphyrin Modified by Low Molecular Weight Chitosan |
| YU Dong-jun1, LI Min-zhi1, HUANG Xian-zhu1, ZHU Wei-hua1, HUANG Yan1, ZHANG Qi1, 2*, LIU Qing1 |
1. Department of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China
2. Hainan Provincial Key Laboratory of Fine Chemistry (Hainan University), Haikou 570228, China |
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Abstract The functional complex Mn-TCPP-CS20 as a potential magnetic resonance imaging (MRI) contrast agent was synthesized through tetra(4-carboxyphenyl) Mn(Ⅱ)-porphyrin (Mn-TCPP) modified by CS20, which was low degree of polymerization and narrow distribution. The results showed that Mn-TCPP-CS20 had good water-solubility and structural stability. The chemical structures of the products were characterized with Fourier transform infrared spectra (FTIR), UV-Vis spectra, mass spectrum (MS) and inductively coupled plasma atomic emission spectrometry (ICP-AES). The results showed that Mn-TCPP was successfully linked to CS20 by an amide function. The relaxation properties in vitro of the functional complex Mn-TCPP-CS20 as the potential MRI contrast agent were preliminarily studied. It was found that the longitudinal relaxivity (r1) of the synthesized Mn-TCPP-CS20 (6.11 mmol-1·L·s-1) was higher than that of the commercial contrast agent Gd-DTPA (r1=3.59 mmol-1·L·s-1). Besides, the imaging effect of Mn-TCPP-CS20 was superior to that of Gd-DTPA in the same condition. These studies suggested that Mn-TCPP-CS20 has the advantage of becoming a potential tissue-targeting contrast agent.
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Received: 2013-01-24
Accepted: 2013-04-16
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Corresponding Authors:
ZHANG Qi
E-mail: qzhang@ujs.edu.cn
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