| 光谱学与光谱分析 |
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| Study on Extractive Spectrophotometry for Determination of Amoxicillin with Ionic Associate |
| DUAN Ya-li1, DU Li-ming2*，CHEN Cai-ping1 |
1. College of Chemistry and Material Science, Shanxi Normal University, Linfen 041004, China
2. Center of Analysis and Testing, Shanxi Normal University, Linfen 041004, China |
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Abstract A method of extractive spectrophotometry has been proposed for the determination of amoxicillin(AMO). The ion pairs complex of amoxicillin with methylene blue (MB) can be extracted into 1,2-dichloroethane at pH 3.3 and has absorption maximum at 657 nm. The ratio of amoxicillin to methylene blue in the ion pairs complex is 1∶1. The apparent molar obsorptivity of ion pairs complex is 5.0·104 L·mol-1·cm-1 at 657 nm. The calibration graph generated is linear over the range of 0.4-6.8 mg·L-1 drug in solution with a correlation of 0.998 9. The detection limit is 0.01 mg·L-1 and the recovery of AMO is 97.5%-101.3%. The present method has been applied to the determination of amoxicillin in pharmaceutical formulations and urine samples with satisfactory results.
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Received: 2003-11-28
Accepted: 2004-04-20
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Corresponding Authors:
DU Li-ming
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| Cite this article: |
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DUAN Ya-li,DU Li-ming,CHEN Cai-ping. Study on Extractive Spectrophotometry for Determination of Amoxicillin with Ionic Associate [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(11): 1865-1867.
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| URL: |
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https://www.gpxygpfx.com/EN/Y2005/V25/I11/1865 |
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