| 光谱学与光谱分析 |
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| Spectrophotometric Determination of Codeine Through Charge-Transfer Reaction |
| DU Li-ming, LI Li, WU Hao |
| Center of Analysis and Test, Shanxi Normal University, Linfen 041004, China |
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Abstract The charge-transfer reaction of 7,7,8,8-tetracyano-quinodimethane(TCNQ)as a π-electron acceptors with codeine as electron donors was investigated by spectrophotometry. TCNQ was found to react with codeine to produce stable charge-transfer complexes in acetone. Meanwhile, the studied drugs suffer a considerable bathochromic shift (from 216 to 843 nm ). The influential factor of charge-transfer reaction and the optimum conditions for the determination of codeine were investigated in detail. Therefore a simple, rapid and accurate method with a good selectivity for the determination of codeine has been developed. The results show that Beer’s law is obeyed in the ranges 0.1-1.6 μg·mL-1 for codeine. The apparent molar absorptivity of the complex at 843 nm is 1.7×104 L·mol-1·cm-1. Furthermore, the association constants and standard free energy changes were studied, and the mechanism of charge-transfer reaction was explored elementarily. The proposed method has been applied successfully to the determination of codeine in pharmaceutical preparations. The recoveries are from (98.94±0.96)% to (99.12±1.21)%.
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Received: 2005-11-16
Accepted: 2006-02-26
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Corresponding Authors:
DU Li-ming
E-mail: lmd@dns.sxnu.edu.cn
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| Cite this article: |
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DU Li-ming,LI Li,WU Hao. Spectrophotometric Determination of Codeine Through Charge-Transfer Reaction[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(02): 364-366.
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| URL: |
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https://www.gpxygpfx.com/EN/Y2007/V27/I02/364 |
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