光谱学与光谱分析 |
|
|
|
|
|
The Study on the Far-FTIR and THz Spectra of Azitromycin Drugs with Different Physical Forms |
YANG Yu-ping1, FAN Li-jie1, 3, CUI Bin1, CHEN Gen-xiang1, ZHANG Zhen-wei2*, ZHANG Cun-lin2 |
1. School of Science, Minzu University of China, Beijing 100081, China 2. Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Department of Physics, Capital Normal University, Beijing 100048, China 3. School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing 100044, China |
|
|
Abstract Far Fourier transform infrared spectroscopy (Far-FTIR) and terahertz time-domain spectroscopy (THz-TDS) were used to measure the fingerprint spectra of Azitromycin suspension, capsule, tablet and dispersible tablet under vacuum and nitrogen conditions, respectively. In the frequency range of 0.2~15 THz, highly resolved spectral features for Azitromycin suspension were measured and some minor differences were observed between domestic and exotic Azitromycin Suspension, such as linewidth broadening and additional peaks. As same time, for the domestic Azitromycin capsule, tablet and dispersible tablet, the absorption baselines in the range of 0.2~2.7 THz rise with the increase of frequency while absorption peaks become weaker due to the scattering of bigger particles and smaller amount of Azitromycin. Also, the additional peaks are caused by the absorption of filling materials. In parallel with the qualitative measurement, the THz absorption spectra for mixtures of polyethylene (PE) powders and exotic Azithomycin suspension with different concentrations were also measured. According to the linear correlation between the concentration and the absorption intensity, the concentration of effective component can be evaluated accurately. This means that THz-TDS method is suitable for the quality inspection and evaluation of the mixed Azithromycin system.
|
Received: 2014-06-12
Accepted: 2014-10-22
|
|
Corresponding Authors:
ZHANG Zhen-wei
E-mail: zhangzw_cnu@163.com
|
|
[1] State Pharmacopoeia Commission of China(国家药典委员会). Pharmacopoeia of the People’s Republic of China (Ⅱ)(中华人民共和国药典·二部). Beijing: Chemical Industry Press(北京:化学工业出版社),2010, 396. [2] State Pharmacopoeia Commission of China (国家药典委员会). Atlas of Infrared Spectra of Drugs (Ⅱ)(药品红外光谱集·第3卷). Beijing: Chemical Industry Press(北京:化学工业出版社),2000, 772. [3] YANG Yu-ping, DONG Rui-lin, ZHANG Zhen-wei( 杨玉平,董睿林,张振伟). Spectroscopy and Spectral Analysis(光谱学与光谱分析),2012,32(11):3035. [4] Yang Y P, Harsha S S, Shutler A J, et al. Journal of Pharmaceutical and Biomedical Analysis, 2012,62:177. [5] Harsha S S,Grischkowsky D. Journal of Physical Chemistry A, 2010,114:3489. [6] Yang Yuping, Lei Xiangyun, Yue Ai, et al. Science China: Physics, Mechanics & Astronomy, 2013,56:713. [7] ZHANG Zhen-wei, ZUO Jian, ZHANG Cun-lin(张振伟,左 剑,张存林). Spectroscopy and Spectral Analysis(光谱学与光谱分析),2012,32(4):906. [8] LIU Da-yong, WANG Wen-hao, SHI Wen-zhong(刘大勇,王文豪,时文中). Journal of Tianzhong(天中学刊),2009,24:11. [9] The United States Pharmacopeial Convention, Inc. The United States Pharmacopceia, Philadelphia: National Publishing, 1999,24:185. |
[1] |
YU Yang1, ZHANG Zhao-hui1, 2*, ZHAO Xiao-yan1, ZHANG Tian-yao1, LI Ying1, LI Xing-yue1, WU Xian-hao1. Effects of Concave Surface Morphology on the Terahertz Transmission Spectra[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(09): 2843-2848. |
[2] |
CHU Zhi-hong1, 2, ZHANG Yi-zhu2, QU Qiu-hong3, ZHAO Jin-wu1, 2, HE Ming-xia1, 2*. Terahertz Spectral Imaging With High Spatial Resolution and High
Visibility[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2023, 43(02): 356-362. |
[3] |
LU Xue-jing1, 2, GE Hong-yi2, 3, JIANG Yu-ying2, 3, ZHANG Yuan3*. Application Progress of Terahertz Technology in Agriculture Detection[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(11): 3330-3335. |
[4] |
TANG Xin, ZHOU Sheng-ling*, ZHU Shi-ping*, MA Ling-kai, ZHENG Quan, PU Jing. Analysis and Identification of Terahertz Tartaric Acid Spectral
Characteristic Region Based on Density Functional Theory and
Bootstrapping Soft Shrinkage Method[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(09): 2740-2745. |
[5] |
LI Yan1, LIU Qi-hang2, 3, HUANG Wei1, DUAN Tao1, CHEN Zhao-xia1, HE Ming-xia2, 3, XIONG Yu1*. Terahertz Imaging Study of Dentin Caries[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(08): 2374-2379. |
[6] |
CHEN Yan-ling, CHENG Liang-lun*, WU Heng*, XU Li-min, HE Wei-jian, LI Feng. A Method of Terahertz Spectrum Material Identification Based on Wavelet Coefficient Graph[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(12): 3665-3670. |
[7] |
LIU Yan-de, XU Zhen, HU Jun, LI Mao-peng, CUI Hui-zhen. Research on Variety Identification of Fritillaria Based on Terahertz Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(11): 3357-3362. |
[8] |
WANG Wen-ai, LIU Wei*. Terahertz Spectroscopy Characteristics of Sugar Compounds[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(08): 2391-2396. |
[9] |
MIAO Xin-yang1,2,3, LIU Xue-cong1,3, CHEN Meng-xi3, CHEN Si-tong3, ZHANG Shan-zhe1, LU Wan-ting3, PENG Xue3, ZHAN Hong-lei2,3, ZHU Ming-da1, ZHAO Kun1,2,3*. Terahertz Spectral Characteristics of Rocks With Different Lithologies[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(04): 1314-1319. |
[10] |
ZHU Rong-sheng1, 2, SHEN Tao1, 2*, LIU Ying-li1, 2, ZHU Yan1, 2, CUI Xiang-wei1, 2. Wasserstein GAN for the Classification of Unbalanced THz Database[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(02): 425-429. |
[11] |
College of Information Science and Technology, Nanjing Forestry University, Nanjing 210037, China
. Investigation on Terahertz Spectroscopy of Food Additives Based on Dispersion-Correction Functional Theory[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(01): 100-104. |
[12] |
SONG Xue-yan1, LI Yan1, XIA Qi-ying2*, JU Xue-hai1*. Theoretical Study on Terahertz Spectra of TKX-50[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(10): 3056-3060. |
[13] |
HU Yin, WANG Min-chang, PAN Qing, NING Yan-li, KANG Ying, WANG Ming, LUAN Jie-yu, CHEN Zhi-qun. Spectroscopic Analysis of Endo and Exo-Tetrahydrodicyclopentadiene[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(10): 3161-3166. |
[14] |
LU Mei-hong1, GONG Peng2, ZHANG Fan1, WANG Zhi-jun1, FENG Duo1,MENG Tian-hua3. Terahertz and Raman Spectra of EDTA-2Na[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(09): 2707-2712. |
[15] |
LI Chao1, 2, LI Bin2, 3*, ZHANG Li-qiong2, YE Da-peng1*, ZHENG Shu-he1. Terahertz Spectrum Inversion Modeling of Lead Content in Different pH Soils[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(08): 2397-2402. |
|
|
|
|