光谱学与光谱分析 |
|
|
|
|
|
High-Resolution THz Spectra of Six Biological and Pharmaceutical Materials |
YANG Yu-ping1, DONG Rui-lin1, ZHANG Zhen-wei2 |
1. School of Science, Minzu University of China, Beijing 100081, China 2. Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Department of Physics, Capital Normal University, Beijing 100048, China |
|
|
Abstract The temperature dependent vibrational spectra of three biological and pharmaceutical sets, genistein and biochanin A, clenbuterol hydrochloride and salbutamol, as well as ginseng R2 and R3, in the range of 0.2~4.5 THz (6.6~150.0 cm-1) are presented over the temperature range from 295 to 77 K. Although there are only some minor difference in their molecular structures, the spectra of two samples in every group are quite differences in both absorption band positions and their relative intensities, and display strong linewidth narrowing and frequency blue-shift with cooling. Au 77 K, 13 highly resolved spectral features for biochanin A were obtained and the sensitivity of the experiment allows detection of amounts as small as 1.9×10-5 mol of ginseng R3. Such high-resolution THz fingerprint spectra provide a rapid, nondestructive and reliable method for the identification of these pharmaceutical settings molecules.
|
Received: 2012-07-30
Accepted: 2012-09-26
|
|
Corresponding Authors:
YANG Yu-ping
E-mail: ypyang_cun@126.com
|
|
[1] Cogdill R P, Short S M, Forcht R, et al. J. Pharm. Innov., 2006, 1: 63. [2] Fitzgerald A J, Cole B E, Taday P F. J. Pharm. Sci., 2005, 94: 177. [3] Ge M, Liu G F, Ma S H, et al. Bull. Kor. Chem. Soc., 2009, 30: 2265. [4] Png G M, Choi J W, Ng B W-H, et al. Phys. Med. Biol., 2008, 53: 3501. [5] Laman N, Harsha S S, Grischkowsky D. Appl. Spectrosco., 2008, 62: 319. [6] Heinz A, Strachan C J, Gordon K C, et al. J. Pharm. Pharmacol., 2009, 61: 971. [7] Ikeda Y, Ishihara Y, Moriwaki T, et al. Chem. Pharm. Bull., 2010, 58: 76. [8] Ajito K, Ueno U. IEEE Transaction on Terahertz Science and Technology, 2011, 1: 293. [9] Ajito K, Ueno Y, Song H J, et al. Mol. Cryst. Liq. Cryst., 2011, 538: 33. [10] Kawase M, Saito T, Ogawa M, et al. Analytical Sciences, 2011, 27: 209. [11] Zeitler J A, Today P F, Newnham D A, et al. Journal of Pharmacy and Pharmacology, 2007, 59: 209. [12] Miles R E, Zhang X C, Eisele H, et al. Terahertz Frequency Detection and Identification of Materials and Objects., Springer Press, 2007. 251. [13] Shen Y C. International Journal of Pharmaceutics, 2011, 417: 48. [14] Grischkowsky D, Keiding S, Exter M van, et al. J. Opt. Soc. Am. B., 1990, 7: 2006. [15] Laman N, Harsha S S, Grischkowsky D, et al. Opt. Express, 2008, 16: 4094. [16] Harsha S S, Grischkowsky D. J. Phys. Chem. A, 2010, 114: 3489. [17] Shen Y C, Upadhya P C, Linfield E H, et al. Appl. Phys. Lett., 2003, 82: 2350. [18] Yang Y P, Harsha S S, Shutler A J, et al. Journal of Pharmaceutical and Biomedical Analysis, 2012, 62: 177. [19] YANG Yu-ping, ZOU Bin, CHEN Xiao, et al(杨玉平,邹 斌,陈 笑,等). Acta. Opt. Sin.(光学学报), 2011,31: s100502. [20] CHEN Xi-ai, HOU Di-bo, HUANG Ping-jie, et al(陈锡爱,侯迪波,黄平捷,等). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2011, 31(11): 3206.
|
[1] |
REN Yue-ying2, NIU Chen1, 2, WANG Jing-jing1, 2, YANG He1, 2, XU Yong-hua1, 2*, LIU Zhi2*. Effects of Different Light Qualities on Growth and Ginsenoside Contents in Callus of Panax ginseng[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2022, 42(04): 1318-1322. |
[2] |
BAI Jun-peng1, 2, LI Bin1*, ZHANG Shu-juan2, CHEN Yi-mei1. Study on Norfloxacin Concentration Detection Based on Terahertz Time Domain Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(09): 2710-2716. |
[3] |
CHEN Bei1, ZHENG En-rang1*, GUO Tuo2. Application of Various Algorithms for Spectral Variable Selection in NIRS Modeling of Red Ginseng Extraction[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(08): 2443-2449. |
[4] |
ZHANG Tian-yao1,2, ZHANG Zhao-hui1*, ZHAO Xiao-yan1, WEI Qing-yang1, CAO Can1, YU Yang1, LI Ying1, LI Xing-yue1. Polarizability Measurements for Salicylic Acid Embedded in Polymer Matrix Using Terahertz Time-Domain Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(06): 1688-1694. |
[5] |
LIU Cui-ling1, YANG Yu-fei1*, TIAN Fang2, WU Jing-zhu1, SUN Xiao-rong1. Study on Quantitative Analysis of Edible Oil Peroxide Value by Terahertz Time Domain Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(05): 1387-1392. |
[6] |
CHEN Meng-qiu1, HE Ming-xia1*, LI Meng2, QU Qiu-hong2. Application of Interval Selection Methods in Quantitative Analysis of Water Content in Engine Oil by Terahertz Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(05): 1393-1397. |
[7] |
WANG Pu1, HE Ming-xia1*, LI Meng2, QU Qiu-hong2, LIU Rui3, CHEN Yong-de4. Application of Terahertz Spectroscopy in the Detection of Bioactive Peptides[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(09): 2696-2701. |
[8] |
ZHANG Hong-run, JI Hong-yu, ZHAO Ping, LIN Gao-zhao, WANG Fu-he, ZHANG Bo*, SHEN Jing-ling*. Study on Ultraviolet Light-Induced Metal Wire-Grid Polarizer in Terahertz Frequency Range[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2019, 39(07): 2040-2045. |
[9] |
ZHANG Dong-yu1, 2, PENG Xiao-yu1*, TANG Fu1, DU Hai-wei1, LUO Chun-hua2*. Single-Shot Terahertz Time Domain Spectroscopy Techniques[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2019, 39(05): 1377-1385. |
[10] |
LI Hong1, XU Qian1, ZHENG Xiao-li1, XU Hui1*, CHEN Geng2, MENG Qing-guo1*. Study of Stereoselective Interaction Between Ginsenoside Rh2 and Serum Albumin by Spectroscopic Methods and Molecular Docking[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2018, 38(12): 3839-3845. |
[11] |
GUAN Ai-hong1,2, LI Zhi1,2, GE Hong-yi1,2. The Qualitative and Quantitative Detection of Potassium Alum in Sweet Potato Starch Based on Terahestz Time-Domain Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2018, 38(01): 267-270. |
[12] |
LENG Wen-xiu, ZHAN Hong-lei, GE Li-na. Optical Analysis of Two-Component Alkane Mixtures Based on Terahertz Spectrum[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2017, 37(07): 2010-2013. |
[13] |
ZHAN Hao, WU Hong-wei, ZHANG Dong, LIU Meng-ting, TANG Li-ying, LI Hua, WANG Zhu-ju, YANG Bin, YANG Lan, FANG Jing*, FU Mei-hong*. Determination of Calycosin-7-Glucoside and Astragaloside in Astragali Radix with Near Infrared Spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2017, 37(05): 1391-1396. |
[14] |
LIU Jian-wei, SHEN Jing-ling*, ZHANG Bo . Identification of Six Isomers of Dimethylbenzoic Acid by Using Terahertz Time-Domain Spectroscopy Technique [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2015, 35(11): 3041-3045. |
[15] |
HUI Ge1, 2, LIU Wei1, ZHANG Jing-zhou1, ZHOU Tie-li2, WANG Si-ming1, ZHAO Yu1*, ZHAO Bing2 . Study on the Effects of Ginsenoside Rb1 on DPPC Bilayers by Using Thermo-Raman Spectrum and DSC[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2015, 35(08): 2176-2179. |
|
|
|
|