|
|
|
|
|
|
| Differences in the Effects of Night Blue Light and White Light Exposure on Liver Circadian Rhythm and Inflammatory Response |
| LIANG Xin-yue1, 2, ZENG Jing2, AI Chang-peng3, LUO Jie-cheng3, FAN Xiao-jing4, WU Sheng-nan3*, GU Ying1, 2, 3* |
1. Medical School of Chinese PLA, Beijing 100853, China
2. Department of Laser Medicine, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China
3. School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China
4. Department of Endocrinology, the Fifth Medical Centre, Chinese PLA General Hospital, Beijing 100071, China
|
|
|
|
|
Abstract The regulation of circadian rhythm by light is a non-imaging visual function.Non-imaging visual effect cells, mainly intrinsically photosensitive retinal ganglion cells, significantly impact the body's biological rhythm, metabolism, cognition, etc., primarilymediated by blue light. This study aimed to explore the effects of night light exposure on liver circadian rhythm and inflammation. The gerbils were exposed to white and blue light for 1 or 3 hours every night for 10 weeks. The real-time reverse transcription-polymerase chain reaction was used to detect the expression rhythm of liver clock genes; transcriptomics was used to analyze the expression level of all liver genes; hematoxylin-eosin staining was used to detect liver tissue morphology, and immunofluorescence staining was used to detect the level of inflammatory factors in liver tissue. The results showed that light exposure at night significantly disrupted the liver's expression rhythm of Arntl, Clock, Cry1, Nr1d1, Per2, and Rora. Light exposure at night had the most significant effect on liver immune system gene expression. Light exposure at night induced hepatocyte edema and up-regulated the expression of pro-inflammatory factors interleukin 17A and granulocyte-macrophage colony-stimulating factor. In short, exposure to light at night disrupted liver circadian rhythms and triggered an inflammatory response in the liver. This study highlights the critical role of non-imaging visual pathways in hepatic metabolic homeostasis.
|
|
Received: 2024-03-02
Accepted: 2024-05-23
|
|
|
|
Corresponding Authors:
WU Sheng-nan, GU Ying
E-mail: guyinglaser301@163.com; wushengnan@bit.edu.cn
|
|
[1] Masri S, Sassone-Corsi P. Nature Medicine, 2018, 24(12): 1795.
[2] Crane B R, Young M W. Annual Review of Biochemistry, 2014, 83: 191.
[3] Jud C, Schmutz I, Hampp G, et al. Biological Procedures Online, 2005, 7: 101.
[4] Mohawk J A, Green C B, Takahashi J S. Annual Review of Neuroscience, 2012, 35: 445.
[5] Berson D M, Dunn F A, Takao M. Science, 2002, 295(5557): 1070.
[6] Hattar S, Liao H W, Takao M, et al. Science, 2002, 295(5557): 1065.
[7] Dibner C, Schibler U, Albrecht U. Annual Review of Physiology, 2010, 72: 517.
[8] Ruby N F, Brennan T J, Xie X, et al. Science, 2002, 298(5601): 2211.
[9] Masís-Vargas A, Hicks D, Kalsbeek A, et al. Physiological Reports, 2019, 7(20): e14257.
[10] Guan Q, Li Y, Wang Z, et al. Cells, 2022, 11(23): 3808.
[11] Zhang S, Zhang Y, Zhang W, et al. Ecotoxicology and Environmental Safety，2019, 178: 94.
[12] Zielinska-Dabkowska K M, Schernhammer E S, Hanifin J P, et al. Science, 2023, 380(6650): 1130.
[13] Fonken L K, Nelson R J. Endocrine Reviews, 2014, 35(4): 648.
[14] Gaston K J. Science, 2018, 362(6416): 744.
[15] Mure L S. Frontiers in Neurology, 2021, 12: 636330.
[16] Nagai N, Ayaki M, Yanagawa T, et al. Investigative Ophthalmology & Visual Science, 2019, 60(12): 3786.
[17] Borck P C, Batista T M, Vettorazzi J F, et al. Metabolism, 2018, 85: 250.
[18] Fonken L K, Aubrecht T G, Meléndez-Fernández O H, et al. Journal of Biological Rhythms, 2013, 28(4): 262.
[19] Hotamisligil G S. Immunity, 2017, 47(3): 406.
[20] Hotamisligil G S. Nature, 2017, 542(7640): 177.
[21] Hausberger F X. The Anatomical Record, 1966, 154(3): 651.
[22] Erren T C, Lewis P. European Journal of Epidemiology, 2019, 34(1): 1.
[23] Papagiannakopoulos T, Bauer M R, Davidson S M, et al. Cell Metabolism, 2016, 24(2): 324.
[24] Shan Z, Li Y, Zong G, et al. BMJ, 2018, 363: k4641.
[25] Zhao Y, Lu X, Wan F, et al. Journal of the American College of Cardiology, 2022, 79(21): 2097.
[26] Hotamisligil G S, Shargill N S, Spiegelman B M. Science, 1993, 259(5091): 87.
[27] Kubes P, Jenne C. Annual Review of Immunology, 2018, 36: 247.
|
| [1] |
FAN Xiao-jing1,2, CHEN De-fu3, ZENG Jing2, LIANG Xin-yue1,2, XU Yi-xuan1,2, QIU Hai-xia2*, GU Ying2,3,4*. Impact of Spectral Component of LED Lighting System on Glucose and Lipid Metabolism[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(05): 1644-1651. |
| [2] |
WU Yun-kai1, CAO Hong2, MAO Chang-jie2, GU Zhi-hong1, WANG Yuan3* . Measurement and Comparison of Zn, Fe, Cu, Mn, Cr, Pb and Cd in Rabbit Liver of High-Adipose Group and Normal Group [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2012, 32(11): 3142-3145. |
| [3] |
WENG Di. GFAAS Determination of Trace Amount Cadmium in Shark Liver after Microwave Digestion [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(11): 2147-2149. |
| [4] |
WENG Di. Determination of Mercury in Shark Liver by Cold Atom Fluorescence Spectrometry after Microwave Dissolution [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(12): 2073-2075. |
|
|
|
|
