光谱学与光谱分析 |
|
|
|
|
|
Review on Label-Free Optical Bio-Sensing Technology Based on Whisper-Gallery-Mode |
JIANG Jun-feng1, LIU Tie-gen1, LI Hai-wei1, HUI Rong-qing2, LIU Kun1, ZHANG Yi-mo1 |
1. College of Precision Instrument & Optoelectronics Engineering, Key Lab of Optoelectronics Information Technology & Science, Ministry of Education, Tianjin University, Tianjin 300072, China 2. Electrical Engineering & Computer Science, University of Kansas, Lawrence, KS 66045, USA |
|
|
Abstract Optical biosensors are becoming an important tool for drug research and life science, and the label-free optical biosensor based on whisper-gallery-mode (WGM) is reviewed in the present paper. The WGM-based sensors are categorized into three types according to the microcavity structure. The biosensor using microsphere got extensive research because of high quality factor, and its response to protein, virus, and bacteria had been studied. The models based on single photon resonant state and perturbation theory were established. The biosensor using microdisk was proposed early since it can make use of mature lithography technology; however, the quality factor was increased greatly only after the thermal reflow process was introduced and single molecule measurement was then realized. The biosensor using microring has simpler mode structure and materials such as polymer, silicon nitride and silicon-on-insulator had been used for sensor fabrication. As a 3-dimension expansion, sensor using microtube can combine the optical channel and fluidic channel, which attracting more and more attention.
|
Received: 2010-01-10
Accepted: 2010-04-20
|
|
Corresponding Authors:
JIANG Jun-feng
E-mail: jiangjfjxu@tju.edu.cn
|
|
[1] Rebecca L. Rich David G. Myszka J. Mol. Recgnit., 2008, 21: 355. [2] Rebecca L Rich, David G Myszka. J. Mol. Recgnit., 2007, 20: 300. [3] Ye Fang. Sensor, 2007, 7: 2316. [4] IIchenko V S, A. B. Matsko A B. IEEE J. Selected Topics Quantum Electron., 2006, 12(1): 15. [5] Vollmer F, Braun D, Libchaber A. Appl. Phys. Lett., 2002, 80(21): 4057. [6] Arnold S, Khoshsima M, Teraoka I, et al. Opt. Lett., 2003, 28(4): 272. [7] Teraoka I, Arnold S, Vollmer F. J. Opt. Soc. Am. B, 2003, 20(9): 1937. [8] Teraoka I, Arnold S. J. Opt. Soc. Am. B, 2006, 23(7): 1381. [9] Ren H, Vollmer F, Arnold S, et al. Opt. Express, 2007, 15(25): 17410. [10] Vollmer F, Arnold S, Keng D. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105: 20701. [11] Teraoka I, Arnold S. J. Opt. Soc. Am. B, 2006, 23(7): 1434. [12] Gaathon O, Culic-Viskota J, Mihnev M, et al., Appl. Phys. Lett., 2006, 89(22): 223901. [13] Teraoka I, Arnold S. Opt. Lett., 2007, 32(9): 1147. [14] Teraoka I, Arnold S. J. Opt. Soc. Am. B, 2009, 26(7): 1321. [15] Blair S, Chen Y. Appl. Opt., 2001,40(4): 570. [16] Boyd R W, Heebner J E. Appl. Opt., 2001, 40(31): 5742. [17] Krioukov E,Klunder D J W,Driessen A,et al. Opt. Lett., 2002, 27(7): 512. [18] Armani D K, Kippenberg T J, Spillance S M, et al. Nature, 2003, 421: 925. [19] Armani A M, Kulkarni R P, Fraser S E, et al. Science, 2007, 317: 783. [20] Chao C Y, Luo L J. Appl. Phys. Lett., 2003, 83(8): 1527. [21] Chao C Y, Guo L J. Appl. Phys. Lett., 2004, 84(14): 2479. [22] Chao C Y, Fung W, Guo L J. IEEE J. Selected Topics Quantum Electron., 2006, 12(1): 134. [23] Ksendzov A, Lin Y. Opt. Lett., 2005, 30(24): 3344. [24] Yalcin A. Popat K C, Aldridge J C, et al. IEEE J. Selected Topics Quantum Electron., 2006, 12(1): 148. [25] Zhan Z Y, Dainese M, Wosinski L, et al. Opt. Express, 2008, 16(7): 4621. [26] Li X, Zhang Z, Qin S, et al. Appl. Opt., 2009, 48(25): 90. [27] White I M, Oveys H, Fan X. Opt. Lett., 2006, 31(9): 1329. [28] Zamora V, Diez A, Andres M V, et al. Opt. Express, 2007, 15(19): 12011. [29] Ling T, Guo L J. Opt. Express, 2007, 15(25): 17424. [30] Bernardi A, Kiravittaya S, Rastelli A, et al. Appl. Phys. Lett., 2008, 93(9): 094106.
|
[1] |
LI Xiu, PAN Jie, HUANG Min*, XI Yong-hui, LIU Zi-han. Influence of Assembly Conditions on Spectral Properties of SiO2 Structural Color Coatings Prepared by Rapid Coating Method[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(07): 2314-2320. |
[2] |
KAN Yu-na, CHEN Bing-wei, ZHAI Sheng-cheng*, MEI Chang-tong. Chemical Compositions of Carbon Sources Affected on Surface Morphology and Spectral Properties of the Synthetic Carbon Microspheres[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(10): 3153-3160. |
[3] |
ZHANG Hao1, 2, XU Yuan-di1, LIU Xiu-yu1. Study on Preparation Mechanism of Ce-Cu/TiO2 Hollow Microspheres with Uniform Particle Size Distribution Based on Fourier Transform Infrared Spectrum and X-Ray Diffraction[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2019, 39(08): 2360-2365. |
[4] |
ZHANG Ai-tang1,3, WANG Rui-zhi1,2, CUI Liang1*, LIU Jing-quan1,3*. Plasmon Adsorption of Gold Nanocaps Modified by Diazonium Salt Molecules[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2019, 39(07): 2073-2076. |
[5] |
LI Bin1,2, NIU Gao2*, YI Yong1, ZHOU Xiu-wen2, LIU Xu-dong2, YE Xin2, WANG Chao-yang3* . Fabrication and Surface-Enhanced Raman Scattering Research on Polystyrene Nanospheres Arrays[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2016, 36(09): 2812-2817. |
[6] |
LI Zhi-quan1, AN Dong-yang1, ZHANG Xin1, ZHAO Ling-ling1, SHA Xiao-peng1, GUO Shi-liang1, LI Wen-chao2 . A Surface Plasmon Micro-Ring Sensor Suitable for Humidity Sensing [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2015, 35(09): 2660-2664. |
[7] |
LI Zhi-quan1, WANG Lu-na1, LI Xin2, ZHANG Xin1. A High Sensitivity Micro-Ring Humidity Sensor Based on U-Shaped Waveguide Coupled Single Micro-Ring Structure [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2015, 35(02): 563-567. |
[8] |
GUO Shi-liang1, HU Chun-hai1, LI Xin2, WANG Wen-juan1 . Study of Spectrum Characteristic of Humidity Sensor Based on Series Coupled Two Micro-Ring Resonators[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2014, 34(11): 3152-3156. |
[9] |
LI Xin1, GUO Shi-liang2, YANG Ming1*, LI Zhi-quan2 . Spectral Characteristics of Novel Accelerometer Based on Optical Microring Resonator [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2014, 34(09): 2327-2330. |
[10] |
PENG Xiao-li1, XU Fang1*, BIAN Jing1, ZHANG Wen-zhong1, WU Yi2 . Fe(Ⅲ) Modified Sodium Alginate Beads Based Micro-Extraction in Combination with Hydride Generation-Atomic Fluorescence Spectrometry (HG-AFS) for Speciation Analysis of Inorganic As(Ⅲ) and As(Ⅴ) in Water Samples[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2013, 33(06): 1689-1692. |
[11] |
LI Zhi-quan, ZHANG Xin*, SUN Yu-chao, LI Xiao-yun, BAI Chun-lei . A New Tunable SOI Micro-Ring Resonator with Three Coupling Points [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2013, 33(05): 1309-1314. |
[12] |
WU Chun-hui1,3, YE Hong-de2, WU De-hong2, YAN Hong2, WANG Xue-mei1*, CHEN Jun4 . Fluorescence Spectroscopic Study on the Biointeraction of New Organometallic Carborane Derivatives with Bovine Serum Albumin[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2013, 33(01): 120-125. |
[13] |
Abderyim Sopahun, Shawket Abliz, Ismayil Nurulla*. Study on the Adsorption Behavior of Beads of Maleic Anhydride-co-Styrene to Pb(Ⅱ) by FAAS[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2012, 32(06): 1677-1680. |
[14] |
SHE Yong-xin, WANG Miao, SHI Xiao-mei, LIU Jia-jia, Lü Xiao-ling, XIAO Hang, CAO Wei-qiang, WANG Jing* . Spectroscopy Study of Binding Mechanisms and Molecular Recognition of Class-Specific Molecularly Imprinted Polymer Beads [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2010, 30(11): 3052-3055. |
[15] |
SHAO Zheng-zheng, ZHANG Xue-ao, WANG Xiao-feng, CHANG Sheng-li . Raman Spectrum Study on Synthesis Mechanism of Porous ZnO Microspheres Assisted with Trisodium Citrate [J]. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2010, 30(05): 1257-1260. |
|
|
|
|