Abstract：A total of two hundred cases of surface Fourier transform infrared (FTIR) spectra from normal female breast were obtained by scanning two hundred enrolled healthy volunteers’ upper limit of the right breast outside the skin with two mid-infrared optical fibers and an attenuated total reflectance (ATR) probe. Twelve characteristic bands of the above FTIR spectra, related to deoxyribonucleic acid, ribonucleic acid, proteins, lipids and carbohydrate were analyzed. Thirty-six spectral parameters of these characteristic bands, including peak positions (P), intensities (I) and full width at half maximum (F) of FTIR spectrums, were statistically analyzed. Meantime, 90% normal reference value range, mean value, standard deviation of above characteristic parameters was obtained and calculated. In present study, we had establish the normal reference range of spectral parameters of characteristic bands in the surface Fourier transform infrared spectra scanned from normal female breast, for the first time. Meanwhile, for further implementation of Fourier transform infrared spectroscopy technique in noninvasive, fast and efficient characteristic clinical diagnosis of breast benign and malignant diseases, these research results was of great importance. Eventually, this study also had made an attempt to explore the profound theoretical basis in the biomedical application of Fourier transform infrared spectroscopy technique.
Key words：Healthy volunteers;Breast;Fourier transform infrared spectra;Reference value
吴 敏，崔 龙，王 港，凌晓锋，赵红梅，徐 智* . 健康人体乳腺傅里叶变换红外光谱特征参数分析 [J]. 光谱学与光谱分析, 2017, 37(03): 733-736.
WU Min, CUI Long, WANG Gang, LING Xiao-feng, ZHAO Hong-mei, XU Zhi* . Analysis of Characteristic Parameters of the Surface Fourier Transform Infrared Spectra from Normal Human Breast . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2017, 37(03): 733-736.
[1] Sun X, Xu Y, Wu J, et al. The Journal of Surgical Research, 2013, 179(1): 33. [2] Zhang Yuanfu, Xu Yizhuang, Weng Shipu, et al. Modem Instrument, 2009, 15(5): 27. [3] Rigas B, Morgello S, Go1dman IS, et al. Proc. Natl. Acad. Sci. USA, 1990, 87(20): 8140. [4] Boydston-White S, Chiriboga L, Diem M, et al. Biophysical Journal, 2000, 78(1): 251A. [5] Dong Liu, Sun Xuejun, Chao Zhang, et al. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 25(122): 288. [6] Ling Zhongming, Xu Lie, Xu Wenping, et al. Chinese Journal of Clinical Medicine, 2008, 15(06): 854. [7] Bai Yuekui, Yu Liwei, Zhang Le, et al. Spectrosc. Spectr. Anal., 2015, 35(3): 599. [8] Fabian H, Thi N A, Eiden M, et al. Biochim. Biophys. Acta, 2006, 1758(7): 874. [9] Walsh M J, Kajdacsy-Balla A, Holton S E, et al. Vib Spectrosc. 2012, 5(60): 23. [10] Lisa M Miller, Megan W Bourassa, Randy J Smith. BBA–Biomembranes, 2013, 1828(10): 2339. [11] Tong Yiping, Lin Yuanwen, Xiao Yulong, et al. Analytical Chemistry, 2002, 30(06): 726. [12] Baker M J, Trevisan J, Bassan P, et al. Nature protocols, 2014, 9(8): 1771. [13] Tian P, Zhang W, Zhao H, et al. British Journal of Surgery, 2015, 102(11): 1372. [14] Shen Wei, Zhao Hongmei, Lei Yutao, et al. Chem. J. Chinese Universities, 2012, 33(11): 2390. [15] Tian P, Zhang W, Zhao H, et al. International Journal of Clinical and Experimental Medicine., 2015, 8(1): 972.
