Study on Error Analysis of Nonlinear Function Coefficient of FAIMS
ZHANG Le-hua1, 2, CHEN Chi-lai1*, LIU You-jiang1, 2, ZHANG Xiao-tian1, 3, WANG Hong-wei1, 2, KONG De-yi1, SUN Wen-jian4, CHENG Yu-peng4
1. State Key Laboratory of Transducer Technology, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, China 2. Department of Automation, University of Science and Technology of China, Hefei 230027, China 3. College of Electronic Science and Applied Physics, Hefei University of Technology, Hefei 230011, China 4. Shimadzu Research Laboratory [Shanghai] CO.LTD., Shanghai 201201, China
Abstract：The solution of ion mobility’s nonlinear function coefficients α2 and α4 is the basis for achieving substance identification of High Field Asymmetric waveform Ion Mobility Spectrometry (FAIMS). Currently, nonlinear function coefficients α2 and α4 lack priors, meanwhile, existed solving results about α2 and α4 are deficient in error evaluation standard. In this article, acetone, isopropanol and 1,2-dichlorobenzene were detected under different dispersion voltage by homemade FAIMS. In general, the spectrum peak of same sample at different dispersion voltage value is unique. Different dispersion voltage and corresponding compensation voltage value determines the value of α2 and α4. According to sample spectra at different dispersion voltage value, groups of spectral characteristics were obtained. Affirmatory number of data which were selected from multiple sets of compensation voltage value and dispersion voltage value, so that they were utilized to solved out lots of α2 and α4. Lots of factor have an effect on the accuracy of the solving results of α2 and α4, for instance, value of compensation voltage and dispersion voltage, style of fetching points of dispersion voltage, and so on. Comparing to other factors, style and amount of dispersion voltage is likely to control. By data analyzing huge amounts of α2 and α4 data, this paper explored their characteristic of distribution and correlation about them，research influence of number and method to fetch dispersion voltage detected points for error of solving results. After fitting frequency of α2 and α4, it was found that they conform to normal distribution, goodness of fitting exceed 0.96, thus standard deviation of their distribution are able to evaluate error of solving results. In addition, a strong correlation exists between them, relevance of sample is -0.977, -0.968, -0.992 respectively. With increasing of computing selected points, the corresponding error of solving results decrease. By comparing the standard deviation of method to fetch dispersion voltage detected points, found that detecting frequency in case of detecting maximum and the 70% of maximum of dispersion voltage value is lower at approximately same standard deviation, solving effect was optimized in unique fetching points style. Based on the premise of ensuring the accuracy of solving results of α2 and α4, it is obvious that reducing the frequency of detections for FAIMS effectively. It created favorable conditions for rapid field detection and precise spectral analysis.
Key words：Nonlinear function coefficient of ion mobility;FAIMS spectrum;Normal distribution;Error
张乐华1，2，陈池来1*，刘友江1, 2，张晓天1, 3，王泓伟1, 2，孔德义1，孙文剑4，程玉鹏4 . 高场不对称波形离子迁移谱非线性函数系数误差分析 [J]. 光谱学与光谱分析, 2015, 35(05): 1153-1158.
ZHANG Le-hua1, 2, CHEN Chi-lai1*, LIU You-jiang1, 2, ZHANG Xiao-tian1, 3, WANG Hong-wei1, 2, KONG De-yi1, SUN Wen-jian4, CHENG Yu-peng4. Study on Error Analysis of Nonlinear Function Coefficient of FAIMS . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2015, 35(05): 1153-1158.
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