Study on the Meningoima Using FT-Mid-IR Spectroscopy
WAN Wei-qing2, PAN Qing-hua1,3, JIA Gui-jun2*, XU Yi-zhuang1, LAI Guo-qiao3, LIU Shao-xuan1, CHEN Jing1, YANG Li-min1, ZHANG Yuan-fu1, WENG Shi-fu1, WU Jin-guang1*
1. College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China 2. Beijing Tian Tan Hospital Affiliated to Capital Medical University,Beijing 100083,China 3. Laboratory of Organosilicon Chemistry and Material Technology,Hangzhou Normal University,Hangzhou 310012,China
Abstract:In the present investigation, 24 cases of meningoima tissues (including 12 cases of benign tumor and 12 cases of malignant tumor 12) were detected using FT-mid-IR spectroscopy linked with attenuated total reflectance (ATR) accessory. These FTIR spectra obtained from the above-mentioned meningoima tissues were analyzed and compared. Significant differences were found in the spectral features of different kinds of meningoima tissues for example fibrous type meningoima and endothelioid meningoima; and for the same type of meningoima tissues the significant differences in the spectram features can be also observed with the increase of grade malignancy. The malignant tumor can be distinguished primarily from benign tumor by the changes of position, shape and intensity of infrared absorption bands, particularly in the ranges of 1 000~1 500 cm-1. The results show that the peak position of the bands (such as 1 160 cm-1) can be used to distinguish the characteristic of meningoima which are in agreement with the pathological results. The accuracy is larger than 85%. These results demonstrate that FT-mid-IR spectroscopy exhibits prospect to develop a novel, non-invasive and rapid method for the diagnosis the brain tumors.
Key words:FT-mid-IR;Attenuate total reflection (ATR);Meningoima
万伟庆2,潘庆华1,3,贾桂军2*,徐怡庄1,来国桥3,刘少轩1, 陈 静1,杨丽敏1,张元福1,翁诗甫1,吴瑾光1* . 傅里叶变换中红外光谱法检测脑膜瘤的研究[J]. 光谱学与光谱分析, 2011, 31(02): 353-356.
WAN Wei-qing2, PAN Qing-hua1,3, JIA Gui-jun2*, XU Yi-zhuang1, LAI Guo-qiao3, LIU Shao-xuan1, CHEN Jing1, YANG Li-min1, ZHANG Yuan-fu1, WENG Shi-fu1, WU Jin-guang1* . Study on the Meningoima Using FT-Mid-IR Spectroscopy . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2011, 31(02): 353-356.