1. 江苏省药品检验所，江苏 南京 210008 2. Department of Chemistry, University of Memphis, Memphis, TN 38152, USA 3. 中国药科大学，江苏 南京 210009
SERS Spectra of Vitamin A Acid in Silver Solution
WANG Yu1, LI Ying-sing2, ZHANG Zheng-xing3, AN Deng-qui3
1. Jiangsu Institute for drug quality control, Nanjing 210008, China 2. Department of Chemistry, University of Memphis, Memphis, TN 38152, USA 3. China Pharmaceutical University, Nanjing 210009, China
Abstract：Vitamin A acid (VAA) was firstly dissolved in chloroform, and then the organic solution containing the samples was mixed with silver sol at the desired concentration. After sufficient shaking, collect SERS spectra of VAA with silver sol layer solution. The attribution of the peaks was illustrated by comparing SERS spectra with NR(Normal Raman) spcetra, and the mechanism and orientation of adsorption were also discussed according to the peaks which was absent in NR spectrum but observed in SERS spectrum. To verify the feasibility of the method for the quantitative analysis, SER spectra at different concentration of VAA were collected. The intensities measured with the band at 1 583 cm-1 were plotted as a function of concentration. It was found that an effective limit for the detection of VAA could be as low as to 1.0×10-7 mol·L-1, the calibration curve was linear in the range from 1.0×10-6-5×10-5 mol·L-1. The proposed method has the potential to quantitative assay of the drugs having SERS effects but undissolvable in water.
Key words：Raman spectroscopy;Surface-enhanced Raman scattering;Vitamin A acid;Undissolvable drug
王 玉1, LI Ying-sing2，张正行3, 安登魁3 . 维生素A酸在银溶胶液中的表面增强拉曼散射光谱 [J]. 光谱学与光谱分析, 2004, 24(11): 1376-1378.
WANG Yu1, LI Ying-sing2, ZHANG Zheng-xing3, AN Deng-qui3 . SERS Spectra of Vitamin A Acid in Silver Solution. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2004, 24(11): 1376-1378.
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