Study on Estimation of Radiation Dose Using FTIR in Mice Thymus
WU Wen-an1, WANG Jian-sheng1*, ZHANG Jia1, MO Fei1, WANG Si-cen3, ZHOU Su-na1, ZHANG Ming-xin1, XU Yi-zhuang2, SHI Jing-sen1, WU Jin-guang2
1. First Hospital of Xi’an Jiaotong University, Xi’an 710061, China 2. Institute of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China 3. College of Pharmacy of Xi’an Jiaotong University, Xi’an 710061, China
Abstract：Fourier transform infrared spectroscopy (FTIR) was applied to study the biochemical changes in the radiation damaged mouse thymus which increased with radiation dose and provided a new method for the estimation of the radiation dose of radiation damaged patients. The results demonstrated that with the dose increasing, the peak positions like 1 550, 1 400, 1 400 and 1 640 cm-1 at the dose of 2, 3 and 5 Gy showed some difference, and there was obvious variance in the intensity: (1) The intensity ratio of 1 085 to 1 236 cm-1 related to nucleic acid tended to decrease. (2) The intensity ratio of 1 640/1 550 decreased. (3) The intensity at 2 958, 2 925, 1 460 and 1 400 cm-1 showed no significant difference. The results suggest that it may be possible for FTIR to become an effective method to estimate the radiation dose in clinic.
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