Spectral Study and Determination of Metoclopramide and Procaine Hydrochloride by Sequential Injection Analysis
WANG Ai-jun, FAN Jing*, FENG Su-ling,CUI Feng-ling
School of Chemical and Environmental Sciences, Key Laboratory of Environmental Science and Engineering of Henan Education Department, Henan Normal University, Xinxiang 453002, China
Abstract：A sequential injection spectrophotometric method is proposed for the determination of metoclopramide or procaine hydrochloride, based on the reactions of metoclopramide and procaine hydrochloride with cerium(Ⅳ) in sulfuric acid medium. Red intermediate products were observed and were found unstable so that their analytical use is only possible by sequential injection technology. For metoclopramide, the detection limit is 6.5 μg·mL-1, and the linear range of determination is 9.7-116.6 μg·mL-1 with a sampling frequency of 45 h-1. For procaine hydrochloride, the detection limit is 7.4 μg·mL-1, and the linear range of the determination is 10.0-130.0 μg·mL-1 with a sampling frequency of 45 h-1. The method has been applied to the determination of metoclopramide and procaine hydrochloride in tablets and injections with satisfactory results as compared with standard method.
王爱军, 樊 静*，冯素玲，崔凤灵 . 甲氧氯普胺和盐酸普鲁卡因顺序注射光谱研究和测定 [J]. 光谱学与光谱分析, 2005, 25(03): 432-435.
WANG Ai-jun, FAN Jing*, FENG Su-ling,CUI Feng-ling . Spectral Study and Determination of Metoclopramide and Procaine Hydrochloride by Sequential Injection Analysis. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(03): 432-435.
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