Study on the Circular Dichroism of (S)- and (R)- Wuweizisu C
LI Yan-feng1, DONG Li-hong3, WANG Wei1, WANG Qiang2, WANG Shu-yang2, ZHAO Peng2, CHANG Jun-biao1, 2*
1. College of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China 2. Department of Chemistry, Zhengzhou University, Zhengzhou 450001, China 3. Henan Key Laboratory of Fine Chemicals, Zhengzhou 450001, China
Abstract：The circular dichroism (CD) is an excellent method for determining the absolute stereochemistry of organic compounds. The CD spectra of four biphenyl compounds were determined by using CD spectrometer, and two pairs of symmetrical CD spectra were obtained. The absolute configuration of biphenyl bond was confirmed by the Cotton effect according to the CD rule. The CD spectrum of compound 3 shows a negative Cotton effect at 256 nm, and a positive Cotton effect at 220 nm, which predicts an S-configuration of biphenyl according to an experimental CD rule. Conversely, the CD spectrum of compound 3’ displays a positive Cotton effect at 256 nm, and a negative Cotton effect at 219 nm, which predicts an R-configuration of biphenyl. And the regularity of oxazoline-mediated Ullmann reaction was obtained, too.
李岩峰1,董黎红3,王 威1,王 强2,王书洋2,赵 鹏2,常俊标1, 2* . S-和R-五味子丙素非对映异构体的圆二色谱研究[J]. 光谱学与光谱分析, 2009, 29(10): 2748-2750.
LI Yan-feng1, DONG Li-hong3, WANG Wei1, WANG Qiang2, WANG Shu-yang2, ZHAO Peng2, CHANG Jun-biao1, 2* . Study on the Circular Dichroism of (S)- and (R)- Wuweizisu C. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2009, 29(10): 2748-2750.
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