Abstract：In recent years, trace physical evidence analysis techniques based on atomic absorption spectroscopy and plasma mass spectrometry have received increasing attention in modern forensic science. Compared with conventional analytical means, atomic absorption spectroscopy and plasma mass spectrometry techniques have the advantages of being fast, sensitive, and simple, but their sensitivity of these techniques is low. Therefore, there is an urgent need for an analytical instrument with high sensitivity, a large range, and the ability to analyze multiple trace elements simultaneously, to meet the requirements for rapid analysis of trace physical evidence in forensic science. Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) is a method that can realize the simultaneous determination of major, trace, and ultra-trace elements. With the advantages of high sensitivity, low detection limit, high spatial resolution, easy operation, and simultaneous determination of multiple elements, this technique has been widely used in in situ microzonation analysis. This paper introduces the advantages of LA-ICP-MS in situ microzonation analysis. For the current status of the application of laser stripping inductively coupled plasma mass spectrometry in forensic science, it reviews the research progress of LA-ICP-MS in situ microzonation analysis technology in the analysis of physical evidence in forensic science, such as glass, hair, inks, gunshot residue (GSR), paper, soil, and so forth, and looks forward to the prospect of the application of this technology.
Key words：Laser ablation inductively coupled plasma mass spectrometry; In situ-microzonation; Forensic science; Physical evidence analysis
刘 松，赵鹏程，陈 伟，叶 祯，彭国彬. 激光剥蚀电感耦合等离子体质谱原位微区分析技术及其在法庭科学领域中的应用进展[J]. 光谱学与光谱分析, 2025, 45(08): 2110-2116.
LIU Song, ZHAO Peng-cheng, CHEN Wei, YE Zhen, PENG Guo-bin. Advances in Laser Ablation Inductively Coupled Plasma Mass
Spectrometry for in Situ Microzonation Analysis and Its
Application in Forensic Sciencec. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2025, 45(08): 2110-2116.
[1] WANG Lan，YANG Li-qin，WANG Ya-ping，et al（王 岚，杨理勤，王亚平，等）. Geological Bulletin of China（地质通报），2012，31（4）: 637.
[2] LUO Yan，HU Sheng-hong，LIU Yong-sheng，et al（罗 彦，胡圣虹，刘勇胜，等）. Chinese Journal of Analytical Chemistry（分析化学），2001，29（11）: 1345.
[3] YANG Liu（杨 柳）. World Nonferrous Metals（世界有色金属），2017，（1）: 130.
[4] ZHU Yan，CHEN Min，QU Hai-yun，et al（朱 燕，陈 敏，屈海云，等）. Chinese Journal of Analytical Science（分析化学），2015，43（1）: 151.
[5] Eckert S L，James W D. Journal of Archaeological Science，2011，38（9）: 2155.
[6] HU Sheng-hong，ZHANG Ding-wen，ZHANG Li-ping，et al（胡圣虹，张鼎文，张丽萍，等）. Metallurgical Analysis（冶金分析），2021，41（12）: 39.
[7] LIU Jin-hui，ZHENG Ling-na，WANG Bing，et al（刘金辉，郑令娜，汪 冰，等）. Journal of Analytical Science（分析科学学报），2020，36（3）: 443.
[8] LI Xiu-yu, LI Wen-hai, MU Tai-lifu，et al (李秀云, 李文海, 木台力甫, 等). Analysis and Testing Technology and Instruments（分析测试技术与仪器）, 2019, 25(4): 260.
[9] HOU Ke-jun，LI Yan-he，TIAN You-rong（侯可军，李延河，田有荣）. Mineral Deposits（矿床地质），2009，28（4）: 481.
[10] CHEN Lu（陈 璐）. Master Dissertation(硕士论文). China University of Geosciences (Wuhan)[中国地质大学(武汉)]，2011.
[11] Cui Wenxin，Cai Zhaoqing，Li Qing，et al. Talanta，2023，255: 124248.
[12] Grainger M N C，Manley-Harris M，Coulson S. Journal of Analytical Atomic Spectrometry，2012, 27（9）: 1413.
[13] Lee S W，Ryu J S，Min J S，et al. Rapid Communications in Mass Spectrometry，2016，30: 1612.
[14] Trejos T，Koons R，Becker S，et al. Analytical and Bioanalytical Chemistry，2013, 405: 5393.
[15] Sjästad K E，Andersen T，Simonsen S L. Spectrochimica Acta Part B: Atomic Spectroscopy，2013，89: 84.
[16] May C D，Watling R J. Forensic Sci. Med. Pathol.，2009，5（2）: 66.
[17] Berends-Montero S，Wiarda W，De Joode P，et al. Journal of Analytical Atomic Spectrometry，2006, 21（11）: 1185.
[18] Almirall J R，Trejos T，Hobbs A，et al. Trace Elemental Analysis of Glass and Paint Samples of Forensic Interest by ICP-MS Using Laser Ablation Solid Sample Introduction. Proceedings of SPIE 5071，2003，5071: 193.
[19] LIU Xia，JIANG Hua（刘 霞, 姜 华）. Journal of the Chinese Criminal Police Academy（中国刑警学院学报），2020，（4）: 104.
[20] Bridge C M，Powell J，Steele K L，et al. Spectrochimica Acta Part B: Atomic Spectroscopy，2007，62（12）: 1419.
[21] Dorn H，Ruddell D E，Heydon A，et al. Canadian Society of Forensic Science Journal，2015，48（2）: 85.
[22] Trejos T，Almirall J R. Talanta，2005，67（2）: 388.
[23] Ash R，He M. Forensic Science International，2018，292，224.
[24] Dressler V L，Pozebon D，Mesko M F，et al. Talanta，2010，82（5）: 1770.
[25] Duncan B R，Hasegawa M，Marshall D A，et al. Analytical and Bioanalytical Chemistry，2021，413（6）: 1571.
[26] Kumtabtim U，Matusch A，Dani S U，et al. International Journal of Mass Spectrometry，2011，307（1-3）: 185.
[27] Fernandes A C B C J，Yang P，Armstrong D Franca R. Talanta, 2023, 265: 124909.
[28] MA Dong，SHEN Min，LUO Yi-wen，et al（马 栋，沈 敏，罗仪文，等）. Spectroscopy and Spectral Analysis（光谱学与光谱分析），2010，30（10）: 2816.
[29] Corzo R, Subedi K, Trejos T, et al. Journal of Forensic Sciences，2016，61（3）: 725.
[30] Alamilla F，Calcerrada M，García-Ruiz C，et al. Forensic Science International，2013，228（1-3）: 1.
[31] LUO Yi-wen，XU Che，ZHANG Qing-hua，et al（罗仪文，徐 彻，张清华，等）. Chinese Journal of Forensic Sciences（中国司法鉴定），2015，（1）: 27.
[32] Subedi K，Trejos T，Almirall J. Spectrochimica Acta Part B: Atomic Spectroscopy，2015，103: 76.
[33] Ferreira I M D，Braz B F，da Silva L，et al. Spectrochimica Acta Part B: Atomic Spectroscopy，2021，177: 106087.
[34] Aliste M, Arranz S, Sanchez-Ortega A, et al. Journal of Forensic Sciences，2020，65（4）: 1094.
[35] Abrego Z, Ugarte A, Unceta N，et al. Analytical Chemistry，2012，84（5）: 2402.
[36] van Es A, de Koeijer J，van der Peijl G. Science & Justice，2009，49（2）: 120.
[37] Trejos T，Flores A，Almirall R J. Spectrochimica Acta Part B: Atomic Spectroscopy，2010，65（11）: 884.
[38] GAO Ting，GUO Hong-ling，QUAN Yang-ke（高 婷，郭洪玲，权养科）. Forensic Science and Technology（刑事技术），2013，（6）: 3.
[39] Arroyo L，Trejos T，Hosick T，et al. Environmental Forensics，2010，11（4）: 315.
[40] Jantzi S C，Almirall J R. Applied Spectroscopy，2014，68（9）: 963.
[41] Shaheen E M，Tawfik W，Mankoula F A，et al. Environmental Science and Pollution Research，2021，28（27）: 1.
