Research Progress of Surface-Enhance Raman Scatting Spectrum for
miRNAs Detection
LIU Hui-qiao1, 2, FU Jin-jin1, WANG Si-tian1, ZHANG Jia-kun1, HE Ya-nan1, CAO Kang-zhe1
1. College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang 464000, China
2. Xinyang Key Laboratory of Functional Nanomaterials for Bioanalysis, Xinyang 464000, China
Abstract：Surface-enhance Raman scatting (SERS) has been widely used in biomedical detection due to its high sensitivity, non-invasive, multi-channel detection and other characteristics. The abnormal expression of microribonucleic acid （miRNAs） has been found to be associated with a variety of diseases, and miRNAs have become a novel biomarker. The development of simple, sensitive and reliable miRNAs detection methods is of great significance for studying biological function, medical diagnosis, disease treatment and targeted drug research of miRNAs. Nano-SERS probes combined with nucleic acid signal amplification strategy showed high sensitivity for miRNAs detection. However, the components in the actual samples are complex, resulting in background signal interference detection results, and the tedious separation and purification process increases the detection time. Researchers have recently combined other techniques to optimize detection, improve sample throughput, simplify operations, reduce analysis time, and improve resolution. This paper mainly introduces the latest progress in miRNAs detection method based on SERS technology, discusses the advantages and necessity of technology fusion, and summarises the existing problems of miRNAs detection based on SERS technology for clinical detection, aiming to provide a reference for the design of a new fast, sensitive and reliable miRNAs detection platform.
刘会俏，付金金，王思甜，张家坤，何亚楠，曹康哲. 表面增强拉曼散射光谱在miRNAs检测中的研究进展[J]. 光谱学与光谱分析, 2024, 44(08): 2111-2119.
LIU Hui-qiao, FU Jin-jin, WANG Si-tian, ZHANG Jia-kun, HE Ya-nan, CAO Kang-zhe. Research Progress of Surface-Enhance Raman Scatting Spectrum for
miRNAs Detection. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2024, 44(08): 2111-2119.
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