Fast Discrimination of Drugs by Improved Projection Algorithm Based on Raman Spectroscopy
JIA Nan-nan, JI Jiang, GAO Peng-fei, RUAN Bin, TAO Zhen-qiang, LI Long-tan, LI Xiao, GUO Han-ming*
Engineering Research Center of Optical Instrument and System, Ministry of Education, Shanghai Key Lab of Modern Optical System, School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
Abstract：The projection algorithm used in mixture analysis to determine whether there is unknown disturbance existing in grey system can not accurately identify different samples and similar samples at the same time when it is used in the identification of drugs, because of the insufficient criteria. In the present study, one of its criteria for whether the size of measurement error of testing sample is at a limited level is improved for whether the size and distribution of measurement error is equal and similar between testing sample and standard sample. By testing 6 kinds of normal drugs(including BAYER Aspirin Enteric-coated Tablets, TYLENOL Acetaminophen Sustained Release Tablets, BAYER Compound Paracetamol Tablets(Ⅱ), HUAZHONG Compound Vitamin C, HUAZHONG Vitamin B and MADINGLIN Demperidone Tablets) and 3 kinds of similar drugs of aspirin(including BAYER Aspirin Enteric-coated Tablets, Shanghai SINE Aspirin Enteric-coated Tablets and Bamyl Aspirin Effervescent Tablets), it was found that the un-improved projection algorithm directly used in discrimination of drugs shows poor performance with many problems existing, however, the improved projection algorithm can discriminate different drugs and similar drugs with accuracy up to 100%. The improved projection algorithm can be a universal, accurate and reliable automated pharmaceutical identification algorithm and can provide a reference for the study on identification of substance.
Key words：Raman spectroscopy;Projection algorithm;Discrimination of drugs;p-value test
贾南南，季 江，高鹏飞，阮 斌，陶振强，李龙潭，李 骁，郭汉明* . 基于拉曼光谱的改进投影算法快速鉴别药品 [J]. 光谱学与光谱分析, 2015, 35(05): 1271-1275.
JIA Nan-nan, JI Jiang, GAO Peng-fei, RUAN Bin, TAO Zhen-qiang, LI Long-tan, LI Xiao, GUO Han-ming* . Fast Discrimination of Drugs by Improved Projection Algorithm Based on Raman Spectroscopy . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2015, 35(05): 1271-1275.
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