Study on Brain Tissue Characteristics of Rat Model of Parkinson’s Disease Based on Functionality Near-Infrared Spectroscopy (fNIRs) Technology
HU Guang-xia1, QIAN Zhi-yu1*, SUN Tao2, YANG Tian-ming3, WANG Wen-hong3
1. Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China 2. Department of Neurosurgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China 3. Department of Neurosurgery, Zhongda Hospital, Southeast University, Nanjing 210009, China
Abstract:Functionality near infrared spectroscopy(fNIRs) technology was utilized in the present paper to explore functional properties of brain tissue of rat model of Parkinson’s disease(PD). Imaging data of rat model were detected by small animal MRI and CT; and characteristic parameters of striatum of rat brain were detected by fNIRs system. Experimental results show that, between PD and normal rat, there is no obvious change in morphological structure, but significant differences existed in reduced scattering coefficient (μ′s) and cerebral blood volume(CBV) of rat striatum; there exists correlation between parameters(μ′s, CBV) obtained by fNIRs and parameters (cerebral blood flow(CBF), CBV) obtained by CT perfusion(CTP). These results indicate that fNIRs can be used as important reference for PD research.
胡光霞1, 钱志余1*, 孙 涛2, 杨天明3, 王文宏3 . 基于功能近红外光谱技术(fNIRs)的帕金森病大鼠模型脑组织特性研究[J]. 光谱学与光谱分析, 2010, 30(09): 2360-2364.
HU Guang-xia1, QIAN Zhi-yu1*, SUN Tao2, YANG Tian-ming3, WANG Wen-hong3 . Study on Brain Tissue Characteristics of Rat Model of Parkinson’s Disease Based on Functionality Near-Infrared Spectroscopy (fNIRs) Technology. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2010, 30(09): 2360-2364.
[1] Mcleod A D, Igielman F, Elwell C, et al. Anesthesia and Analgesia, 2003, 97(3): 851. [2] Brawanski A, Faltermeier R, Rothoerl R F, et al. Journal of Cerebral Blood Flow Metab., 2002, 22(5): 605. [3] Asgari S, Rohrborn H J, Engelhorn T, et al. Neurosurgery, 2003, 52(6): 1298. [4] Al-Rawi P G, Smielewski P, Kirkpatrick P J. Stroke, 2001, 32(11): 2492. [5] Vets P, Broecke P, Adriaensen H, et al. Acta Anaesthesiol Belg., 2004, 55(3): 215. [6] Asgari S, Rohrborn H J, Engelhorn T, et al. Acta Neurochirurgica, 2003, 145(6): 453. [7] Soul J S, Eichenwald E, Walter G, et al. Pediatr. Res., 2004, 55(5): 872. [8] Shojima M, Watanabe E, Mayanagi Y. Surg Neurol., 2004, 62(4): 312. [9] Watanabe E, Nagahori Y, Mayanagi Y. Epilepsia, 2002, 43(9): 50. [10] Haginoya K, Munakata M, Kato R, et al. Brain, 2002, 125(9): 1960. [11] Buchheim K, Obrig H, Pannwitz W, et al. Neurosci. Lett., 2004, 354(2): 119. [12] Macnab A J, Gagnon R E, Gagnon F A. Spine, 2002, 27(1): 17. [13] Macnab A J, Gagnon R E, Gagnon F A, et al. Spectroscopy-An International Journal, 2003, 17(2-3): 483. [14] ZHANG Yao-fen, DUAN De-yi, XU Qun-yuan(张耀芬,段德义,徐群渊). Progress of Anatomical Sciences(解剖科学进展), 2005, 11(1): 49. [15] QIAN Zhi-yu, CHEN Ren-wen, GU Yue-qing, et al(钱志余,陈仁文,顾月清,等). Journal of Nanjing University of Aeronautics & Astronautics(南京航空航天大学学报), 2004, 36(3): 369. [16] QIAN Zhi-yu, GU Yue-qing, LIU Han-li, et al(钱志余,顾月清,刘汉莉,等). Chinese Journal of Medical Physics(中国医学物理学杂志), 2005; 22(2): 463. [17] Langston J W, Quik M, Petzinger G, et al. Ann. Neurol., 2000, 47(1): 79. [18] Podell M, Hadjiconstantinou M, Smith M A, et al. Exp. Neurol., 2003, 179(2): 159. [19] Brownell A L, Canales K, Chen Y I, et al. Neuro. Image, 2003, 20(2): 1064. [20] Van Laere K, Santens P, Bosman T, et al. J. Nucl. Med., 2004, 45(6): 933. [21] Cilia R, Marotta G, Landi A, et al. Eur. J. Neurol., 2008, 15(1): 22. [22] LI Wei-tao, QIAN Zhi-yu, WANG Hui-nan, et al(李韪韬,钱志余,王惠南,等). Acta Photonica Sinica(光子学报), 2006, 35(5): 712.