1. Tianjin University of Traditional Chinese Medicine，Tianjin 300193, China 2. Department of Chemistry，Tsinghua University，Beijing 100084, China 3. College of Pharmacy，Tianjin Medical University，Tianjin 300070, China 4. Tianjin Nankai Hospital，Tianjin 300100, China
Abstract：Fourier transform spectroscopy (FTIR) and two-dimensional correlation spectroscopy were used to analyze different compatibility forms of sargentgloryvine stem, radix paeoniae rubra and cortex moutan in order to study the FTIR spectra of different proportion formulas. The results indicate that different proportion formulas have distinct change regularity in FTIR spectra, second derivative spectra and synchronous 2D. Key components of sargentgloryvine stem’s characteristic absorption band are 1 610, 1 518 and 1 446 cm-1 which are characteristic absorption band of aromatic material, and in the original formula, that shows stronger peak than others, suggesting that original formula can make the best of composition of drug action. In the different proportion formulas, 1 614 cm-1 is nearer to 1 610 cm-1, which is sargentgloryvine stem’s characteristic absorption band, than to 1 706 cm-1, illustrating that sargentgloryvine stem is more influential formula than others. According to identification and ascription of characteristic absorption band, it was initially revealed that different proportion of drug dosage can affect pharmacodynamic action of integral formula.
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