1. Department of Chemistry, Suzhou University, Suzhou 215123，China 2. Department of Chemistry, State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005，China
Abstract：Labeled immunoassay utilizing surface-enhanced Raman spectroscopy (SERS) is a new-style research technology. The discovery and confirmation of surface-enhanced Raman spectroscopy have made Raman spectroscopy a powerful tool in many research fields. SERS has the advantages such as high sensibility and selectivity, also it is suitable for the study of liquid substance. In recent years, it has shown potential application future in biomedical field, and also developed fast in labeled immunoassay. The principle, specialty, problem and recent advances of labeled immunoassay based on SERS were reviewed in terms of detection limits, non-specific adsorption and multi-analyte immunoassay. The latest advancement in the improvement of detection limits was summarized, along with the introduction of some work in our lab, as well as expatiating on the effect of non-specific adsorption. Finally, the development trends and application perspectives were discussed.
葛明1,崔颜2,顾仁敖1*. SERS标记免疫检测研究进展[J]. 光谱学与光谱分析, 2008, 28(01): 110-116.
GE Ming1,CUI Yan2,GU Ren-ao1*. Progress in Labeled Immunoassay Based on SERS. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2008, 28(01): 110-116.
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