三种环氧孕甾衍生物的合成和光谱特性研究

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摘要：合成了三种环氧孕甾衍生物：6-亚甲基-16α,17α-环氧孕甾-4-烯-3,20-二酮，6-甲基-16α,17α-环氧孕甾-4，6-二烯-3,20-二酮和6-甲基-16α,17α-环氧孕甾-4-烯-3,20-二酮。其中6-甲基-16α,17α-环氧孕甾-4，6-二烯-3,20-二酮未见文献报道。同时应用红光谱(FTIR)、紫外光谱(UV)、及核磁共振氢谱(¹H NMR)对三种甾体化合物的结构进行了研究。结果表明，三种甾体化合物结构上的差异在FTIR，UV，¹H NMR谱中有明显的特征并表现出一定的规律。

关键词：孕甾;甾体;红外光谱;紫外光谱;核磁共振氢谱

Abstract：Three kinds of derivatives, 16α,17α-epoxy-6-methylene-pregn-4-ene-3,20-dione(EMPD Ⅰ), 16α,17α-epoxy-6-methyl-pregn-4,6-diene-3,20-dione (EMPD Ⅱ) and 16α,17α-epoxy-6-methyl-pregn-4-ene-3,20-dione(EMPD Ⅲ) were synthesized and their FTIR，UV and ¹H NMR spectra were described. EMPD Ⅱ is a novel compound. In the UV spectra, the maximum absorptions peaks of EMPD Ⅰ, EMPD Ⅱ and EMPD Ⅲ are at 259, 287 and 239 nm respectively. Their IR spectra are also obviously different. For EMPD Ⅰ, there are two absorption peaks, which are respectively at 3 084 cm^-1 originated from CH₂ and 3 030 cm^-1 from CCH. For EMPD Ⅱ and Ⅲ, there is only one absorption peak at 3 054 cm^-1. From 1 710-1 660 cm^-1,only one absorption peak appears for EMPD Ⅲ, but two appear for EMPD Ⅰ and EMPD Ⅱ. In ¹H NMR spectrum, the peaks at 4.92(s, 1H), 5.06(s, 1H) and 5.88(s, 1H) were observed for EMPD Ⅰ; the peaks at 1.83(s, 3H), 5.87(s, 1H) and 5.85(s, 1H) for EMPD Ⅱ; while the peaks at 1.06-1.07(d, 3H), 5.78 ppm(s, 1H, 1 ppm=1 μg·mL^-1), for EMPD Ⅲ.

Key words：Pregnene;Steroid;FTIR;UV;¹H NMR

收稿日期: 2006-05-08 修订日期: 2006-08-16

中图分类号:

O622.4

通讯作者: 尹海滨 E-mail: hmikeyin@hotmail.com

引用本文:

尹海滨,郑虎. 三种环氧孕甾衍生物的合成和光谱特性研究[J]. 光谱学与光谱分析, 2007, 27(05): 966-968.
YIN Hai-bin,ZHENG Hu. Synthesis and Spectral Analysis of Three Kinds of Epoxy Pregnene Derivatives. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2007, 27(05): 966-968.

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